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BACKGROUND AND PURPOSE To evaluate the long-term survival outcomes and toxicity of NPC patients treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS From May 2001 to October 2008, 868 non-metastatic NPC patients treated by IMRT were analyzed retrospectively. The Radiation Therapy Oncology Group (RTOG) criteria were used to assess(More)
PURPOSE Reports of intensity-modulated radiotherapy (IMRT) for early-stage nasopharyngeal carcinoma (NPC) have been limited. The present study evaluated the long-term survival outcomes and toxicity of early-stage NPC patients treated with IMRT alone. METHODS AND MATERIALS Between February 2001 and January 2008, 198 early-stage (T1-T2bN0-N1M0) NPC patients(More)
BACKGROUND The H3K4 demethylase retinoblastoma binding protein 2 (RBP2) is involved in the pathogenesis of gastric cancer, but its role and regulation in hepatocellular carcinoma (HCC) is unknown. We determined the function of RBP2 and its regulation in HCC in vitro and in human tissues. METHODS We analyzed gene expression in 20 specimens each of human(More)
Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis. The expression levels of miR-370 and FoxM1 were assessed in 48 newly diagnosed AML patients, 40 AML patients in 1st complete remission (CR) and 21 healthy(More)
901 Mitoxantrone Targets Human UbiquitinSpecific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Survival Richard A. Burkhart, Yu Peng, Zo€e A. Norris, Ren ee M. Tholey, Vanessa A. Talbott, Qin Liang, Yongxing Ai, Kathy Miller, Shruti Lal, Joseph A. Cozzitorto, Agnieska K. Witkiewicz, Charles J. Yeo, Matthew Gehrmann, Andrew Napper,(More)
Acetone-butanol-ethanol (ABE) fermentation by combining a PDMS membrane bioreactor and Clostridium acetobutylicum was studied, and a long continuous and closed-circulating fermentation (CCCF) system has been achieved. Two cycles of experiment were conducted, lasting for 274 h and 300 h, respectively. The operation mode of the first cycle was of fermentation(More)
BACKGROUND Salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC) is complicated and relatively limited. Radiotherapy, combined with effective concomitant chemotherapy, may improve clinical treatment outcomes. We conducted a phase II randomized controlled trial to evaluate the efficacy of intensity-modulated radiotherapy with concomitant(More)
In this systematic review and meta-analysis, the effect of ovarian endometrioma on ovarian responsiveness to stimulation and on assisted reproduction outcomes was evaluated. Nine published studies (1039 cases) were included. The number of oocytes retrieved (mean difference [MD] -1.50; 95% CI, -2.84 to -0.15, P = 0.03), metaphase II (MII) oocytes retrieved(More)
A target-specific MRI contrast agent for tumor cells expressing high affinity folate receptor was synthesized using generation five (G5) ofpolyamidoamine (PAMAM) dendrimer. Surface modified dendrimer was functionalized for targeting with folic acid (FA) and the remaining terminal primary amines of the dendrimer were conjugated with the bifunctional NCS-DOTA(More)
Helicobacter pylori is a major human pathogen associated with gastric diseases such as chronic active gastritis, peptic ulcer, and gastric carcinoma. The growth factor progranulin (PGRN) is a secreted glycoprotein that functions as an important regulator of cell growth, migration, and transformation. We aimed to determine the molecular mechanisms by which(More)