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Design, synthesis, and biological evaluation of novel 4-hydroxypyrone derivatives as HIV-1 protease inhibitors.
- Chun-lai Sun, Ruifang Pang, H. Zhang, Ming Yang
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 July 2005
Twenty-four 4-hydroxypyrone derivatives were synthesized with a facile synthetic method to develop novel HIV protease inhibitors. Most of them were shown to display good antiviral activities in… Expand