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Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around the average atmospheric level (0.038%). We demonstrated the expression of carbonic anhydrase type II (CAII), an enzyme that catabolizes CO2, in a subset of(More)
Carbon dioxide (CO(2)) is an important environmental cue for many animal species. In both vertebrates and invertebrates, CO(2) is detected by a specialized subset of olfactory sensory neurons (OSNs) and mediates several stereotypical behaviors. It remains unknown how CO(2) cues are integrated with other olfactory signals in the mammalian olfactory bulb, the(More)
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