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Anti-sense oligonucleotide labeled with technetium-99m using hydrazinonictinamide derivative and N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycline: a comparison of radiochemical behaviors and
TLDR
99m Tc-MAG(3)-ASON shows superior radiochemical behaviors and biological properties than (99m)Tc-HYNIC-ASON and is a potential radiopharmaceutical agent for in vivo application.
[Study on the antisense inhibition effect of liposome-mediated radiolabled antisense oligonucleotides of c-myc mRNA].
TLDR
The liposome-mediated 99mTc-labeled antisense oligonucleotides could prohibit the cancer cells from growing and the oncogene from expressing.
[The radiolabeling property of oligonucleotide with 99mTc using NHS-MAG3 as a chelator].
TLDR
99mTc-ON labeled with NHS-MAG3 method showed superior radiochemical characteristics and the label was stable in serum and the binding with plasma protein was low, suggesting 99mTC-ON could be a sort of potential radiopharmaceutical for in vivo applications.
Study on Labeling of Antisense Oligonucleotides of IgH V1 FR mRNA With ~(125)I
TLDR
The radioiodination method by conjugation of the oligonucleotides with tyramine is very successful and the radiochemical purity of ~(125)I-Tyramine-FR-ASON is over 90% at 24 h in ambient atmosphere.
[Preparation of liposome-mediated 99m-technetium-labeled antisense oligonucleotides of c-myc mRNA].
TLDR
Liposome-mediated radiolabeled antisense oligonucleotides were stable after incubation with water or serum and could be obtained through hydrazino nicotinamide derivatives as di-functional chelate and liposome as vector.
[A comparison on radiochemical behavior and biological property of antisense oligonucleotide labeled with technetium-99m by two methods: NHS-MAG3 versus SHNHP].
TLDR
The results revealed that the radiochemical behavior and biological property of 99mTc- MAG3-ASON labeled using NHS-MAG3 is better than that of 99tc-SHNH-asons labeled using SHNH.
[Study on the biological character of liposome-mediated 99m-technetium labeled antisense oligonucleotide for c-myc mRNA].
TLDR
To probe the biological character of liposome-mediated 99m-technetium-labeled antisense oligonucleotide of c-myc mRNA, and lay the foundations for clinical research on antisense image or treatment, liposomesome- mediated 99mTc-DNA is a potential kind of radioactive agent.