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Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats.
TLDR
The hypotheses that NKB and leptin play an essential role in the activation of GNRH neurons and initiation of increased LH pulse frequency in PNA female rats at puberty are validated and that kisspeptin may coordinate their stimulatory effects on LH release are validated. Expand
Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study
TLDR
It is suggested that PCOS patients with high BMI tend to have functional disorders of androgen excess; therefore, BMI may be a strong predictor of hyperandrogenism in PCOS. Expand
Polymorphism of CAG and GGN repeats of androgen receptor gene in women with polycystic ovary syndrome.
TLDR
The data suggest that the GGN repeat polymorphism in the AR gene is associated with PCOS, a characteristic of polycystic ovary syndrome, which may be related to the activity of androgen receptor (AR). Expand
Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome
TLDR
Results revealed a previously undefined role of CFTR in suppressing glucagon production in α-cells, defects in which may contribute to glucose metabolic disorder seen in CF and PCOS. Expand
Insufficient Cumulus Expansion and Poor Oocyte Retrieval in Endometriosis-Related Infertile Women
TLDR
The lower expression of cumulus expansion–related genes in CCs suggests the insufficient Cumulus expansion in EMs-related infertile women, which partially explains a possible mechanism related to poor oocyte retrieval. Expand