Chun-Yan Lim | Semantic Scholar

Publications
Influence

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The lysosome as a command-and-control center for cellular metabolism

Chun-Yan Lim, Roberto Zoncu

Biology, Medicine

The Journal of cell biology

2016 (First Publication: 12 September 2016)

Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely known as terminal catabolic stations that rid cells of waste products and scavenge metabolic building blocks… Continue Reading

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Vito W. Rebecca, Michael C. Nicastri, +29 authors Ravi K Amaravadi

Biology, Medicine

Cancer discovery

2017 (First Publication: 1 November 2017)

Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as… Continue Reading

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

Rosalie E Lawrence, Simon A Fromm, +8 authors Roberto Zoncu

Chemistry, Medicine

Science

2019 (First Publication: 22 November 2019)

The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase)… Continue Reading