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- Publications
- Influence
The lysosome as a command-and-control center for cellular metabolism
- Chun-Yan Lim, R. Zoncu
- Biology, Medicine
- The Journal of cell biology
- 12 September 2016
Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely known as terminal catabolic stations that rid cells of waste products and scavenge metabolic building blocks… Expand
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
- Rosalie E. Lawrence, S. A. Fromm, +8 authors R. Zoncu
- Chemistry, Medicine
- Science
- 22 November 2019
Cellular response to nutrient status An intricate regulatory mechanism is taking shape around control of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase complex. Physiological… Expand
A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
- V. Rebecca, Michael C Nicastri, +29 authors R. Amaravadi
- Biology, Medicine
- Cancer discovery
- 1 November 2017
Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as… Expand
NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C
- Oliver B. Davis, H. R. Shin, +6 authors R. Zoncu
- Biology, Chemistry
- 2 August 2020
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling… Expand
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
- Oliver B. Davis, H. R. Shin, +6 authors R. Zoncu
- Biology, Medicine
- Developmental cell
- 7 December 2020
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling… Expand