Chun-Yan Lim

Publications
Influence

The lysosome as a command-and-control center for cellular metabolism

Chun-Yan Lim, R. Zoncu
Biology, Medicine
The Journal of cell biology
12 September 2016

Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely known as terminal catabolic stations that rid cells of waste products and scavenge metabolic building blocks… Expand

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

Rosalie E. Lawrence, S. A. Fromm, +8 authors R. Zoncu
Chemistry, Medicine
Science
22 November 2019

Cellular response to nutrient status An intricate regulatory mechanism is taking shape around control of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase complex. Physiological… Expand

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

V. Rebecca, Michael C Nicastri, +29 authors R. Amaravadi
Biology, Medicine
Cancer discovery
1 November 2017

Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as… Expand

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

Oliver B. Davis, H. R. Shin, +6 authors R. Zoncu
Biology, Chemistry
2 August 2020

Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling… Expand

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.

Oliver B. Davis, H. R. Shin, +6 authors R. Zoncu
Biology, Medicine
Developmental cell
7 December 2020

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