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We describe clinical and pathological features of a case of paralytic rabies with acute axonal neuropathy that closely resembled axonal Guillain-Barre syndrome. This case emphasizes that there is overlap of both clinical and pathological features in paralytic rabies and axonal Guillain-Barre syndrome. These findings raise the possibility that infectious and(More)
The effect of serum from a patient with acute motor axonal neuropathy (AMAN) on cultured motor neurons was studied. The ventral spinal ventral tissue was isolated from embryonic rats and digested into dissociated cell suspension for culture in vitro. The cultured cells were stained with SMI-32, a non-phosphorylated neurofilment marker monoclonal antibody to(More)
A subset of patients of amyotrophic lateral sclerosis (ALS) present with mutation of Cu/Zn superoxide dismutase 1 (SOD1), and such mutants caused an ALS- like disorder when expressed in rodents. These findings implicated SOD1 in ALS pathogenesis and made the transgenic animals a widely used ALS model. However, previous studies of these animals have focused(More)
AIMS Heart failure is a common antecedent to atrial fibrillation; both heart failure and atrial fibrillation are associated with increased myocardial oxidative stress. Chronic canine heart failure reduces atrial action potential duration and atrial refractoriness. We hypothesized that inducible nitric oxide synthase 2 (NOS2) contributes to atrial oxidative(More)
C-X-C motif chemokine ligand (CXCL) 9 and CXCL10 play key roles in the initiation and development of acute transplant rejection. Previously, higher levels of RANTES expression and secretion were demonstrated in retransplantation or T-cell memory-transfer models. In the present study, the effect of the chemokines, CXCL9 and CXCL10, were investigated in a(More)
INTRODUCTION Over the last 40 years omega-3 polyunsaturated fatty acids (PUFAs) have been shown to be anti-arrhythmic or pro-arrhythmic depending on the method and duration of administration and model studied. We previously reported that omega-3 PUFAs do not confer anti-arrhythmic properties and are pro-arrhythmic in canine model of sudden cardiac death(More)
Dorsal root ganglia from rat embryos were digested with trypsin to form single cell suspension. The cells were seeded on culture plates coated respectingly with poly-L-lysin (PLL), laminin (LN), PLL combined with LN, or collagen type I (CoI), then cultured in NB1 media. The cell survival and neurite outgrowth of cultured dorsal root ganglion cells were(More)
This study was aimed at developing a method of organotypic culture of spinal cord slice. The slice culture was prepared using lumbar spinal cord from 8-day-old rat. The survival of alpha-motor neuron was evaluated by the morphological observation and by monoclonal antibody SMI-32, a nonphosphorylated neurofilament marker and immunohistochemical staining.(More)
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