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High instruction cache hit rates are key to high performance. One known technique to improve the hit rate of caches is to use an optimizing compiler to minimize cache interference via an improved layout of the code. This technique, however, has been applied to application code only, even though there is evidence that the operating system often uses the(More)
The Active Straight Leg Raise (ASLR) is an important test in diagnosing pelvic girdle pain (PGP). It is difficult to understand what happens normally during the ASLR, let alone why it would be impaired in PGP. In the present study, healthy subjects performed the ASLR under normal conditions, with weight added above the ankle, and while wearing a pelvic(More)
Elderly females, particularly those carrying the apolipoprotein E (ApoE)-ε4 allele, have a higher risk of developing Alzheimer's disease (AD). However, the underlying mechanism for this increased susceptibility remains unclear. In this study, we investigated the effects of the ApoE genotype and gender on the proteome of synaptosomes. We isolated(More)
High-performing on-chip instruction caches are crucial to keep fast processors busy. Unfortunately, while on-chip caches are usually successful at intercepting instruction fetches in loop-intensive engineering codes, they are less able to do so in large systems codes. To improve the performance of the latter codes, the compiler can be used to lay out the(More)
Women with pregnancy-related pelvic girdle pain (PPP), or athletes with groin pain, may have trouble with the active straight leg raise (ASLR), for which a pelvic belt can be beneficial. How the problems emerge, or how the belt works, remains insufficiently understood. We assessed muscle activity during ASLR, and how it changes with a pelvic belt. Healthy(More)
—High instruction cache hit rates are key to high performance. One known technique to improve the hit rate of caches is to minimize cache interference by improving the layout of the basic blocks of the code. However, the performance impact of this technique has been reported for application code only, even though there is evidence that the operating system(More)
Bus-based shared-memory multiprocessors with coherent caches have recently become very popular. To achieve high performance, these systems rely on increasingly sophisticated cache hierarchies. However, while these machines often run loads with substantial operating system activity, performance measurements have consistently indicated that the operating(More)
Despite rapid increases in CPU performance, the primary obstacles to achieving higher performance in contemporary processor organizations remain control and data hazards. Primary data cache misses are responsible for the majority of the data hazards. With CPU primary cache sizes limited by clock cycle time constraints, the performance of future CPUs is(More)
Despite extensive studies on the multifaceted roles of morroniside, the main active constituent of iridoid glycoside from Corni Fructus, the effect of morroniside on osteoarthritis (OA) chondrocytes remains poorly understood. Here, we investigated the influence of morroniside on cultured human OA chondrocytes and a rat experimental model of OA. The results(More)
Peste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the recombinant(More)