Chun-Wei R. Lin

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Previous epidemiology studies have shown association between coal burning and human lung cancer. To confirm relationship of coal burning to lung cancer formation and progression the expression of p53 and c-myc in 13 mouse lung cancer induced by coal-burning smoke and 5 mouse lung tissue control was studied by DNA-RNA in situ hybridization (ISH). Nine of 13(More)
The effect of cholesterol feeding on liver and aortic nonenzymatic lipid peroxidation and glutathione peroxidase activities, and on liver microsomal NADPH-dependent lipid peroxidation, codeine hydroxylation and cytochrome P-450 levels was examined in rats and guinea pigs. One percent cholesterol was added to a casein-sucrose-soybean oil basal diet for rats(More)
The effects of rhubarb on arachidonic acid metabolism in renal medulla of rabbits were studied in vitro with radiochromatography and radioautography. The results showed that radioactive agent was markedly reduced in the rhubarb group and significant difference vs the control was observed (P less than 0.01). The results indicated that rhubarb blocked the(More)
Washed rabbit platelets were incubated with [14C] arachidonic acid (AA sodium salt) after being exposed to 2-naphthyl-3-(3,4-dimethoxy) phenyl-propenoic acid (NM-PA), indomethacin (Ind) and imidazole (Imi) or control solvent. The metabolites of AA in rabbit platelets were separated with the system of chloroform: methanol: acetic acid: water (90:8:1:0.8) by(More)
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