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Assessment of Stromal‐Derived Inducing Activity in the Generation of Dopaminergic Neurons from Human Embryonic Stem Cells
TLDR
Conditioned medium combined with heparin and/or fixed PA6 cells produced TH+ cell differentiation, although less effectively than PA6 cell coculture, but secreted factors are required for the specific DA neuron‐inducing effect. Expand
A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine
TLDR
It is demonstrated that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors and N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development. Expand
CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit
TLDR
It is demonstrated that the effects of cocaine are mediated through CYP3A5-induced generation of reactive oxygen species, inhibition of neocortical progenitor cell proliferation, induction of premature neuronal differentiation, and interruption of neural tissue development, suggesting CYP 3A5 as a therapeutic target to mitigate the deleterious neurodevelopmental effects of prenatal cocaine exposure in humans. Expand
Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3.
TLDR
The role of DcR3 in the development of TAMs was confirmed and elucidates the molecular mechanism of impaired MHC-II-mediated antigen presentation by TAMs, and raises the possibility that subversion of TAM-induced immunosuppression via inhibition of D cR3 expression might represent a target for the design of new therapeutics. Expand
3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
TLDR
The history and current state of 3D brain organoid differentiation strategies, a survey of applications of organoids towards studies of neurodevelopmental and neurodegenerative disorders, and the challenges associated with their use as in vitro models of neurological disorders are described. Expand
Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3).
TLDR
It is demonstrated that DcR3 induces dendritic cell (DC) apoptosis by activating PKC-delta and JNK subsequently to up-regulate DR5 to recruit Fas-associated death domain (FADD) to propagate the apoptotic signals. Expand
Transcriptional profiles of type 2 diabetes in human skeletal muscle reveal insulin resistance, metabolic defects, apoptosis, and molecular signatures of immune activation in response to infections.
TLDR
The essential regulation of impaired insulin signaling and oxidative phosphorylation in the muscle of T2DM patients is confirmed, and novel molecular insights into the pathophysiological mechanisms of T1DM are provided. Expand
Increases in expression of 14‐3‐3 eta and 14‐3‐3 zeta transcripts during neuroprotection induced by Δ9‐tetrahydrocannabinol in AF5 cells
TLDR
The data suggest that increases in 14‐3‐3 proteins mediate THC‐induced neuroprotection under conditions of NMDA‐induced cellular stress. Expand
GABAergic lineage differentiation of AF5 neural progenitor cells in vitro
TLDR
AF5 cells can be induced to differentiate to a neuronal phenotype with a GABAergic lineage, and cellular GABA levels in differentiated AF5 cells increase by about 26-fold, and GABA release into the medium is 150-fold higher compared with that of undifferentiated cells. Expand
Gene Expression Profiling Reveals Distinct Cocaine-Responsive Genes in Human Fetal CNS Cell Types
TLDR
The data suggest that cocaine causes cytoskeletal abnormalities leading to disturbances in neural differentiation and migration in progenitor cells, while altering immune and apoptotic responses in glia, which may help in the development of therapeutic strategies to prevent or ameliorate cocaine-induced impairments in fetal brain development. Expand
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