Entropic switch regulates myristate exposure in the HIV-1 matrix protein.
- Chun Tang, Erin Loeliger, P. Luncsford, I. Kinde, D. Beckett, M. Summers
- BiologyProceedings of the National Academy of Sciences…
- 13 January 2004
These findings indicate that the HIV-1 myristyl switch is regulated not by mechanically induced conformational changes, as observed for other myristy switches, but instead by entropic modulation of a preexisting equilibrium.
Antiviral inhibition of the HIV-1 capsid protein.
- Chun Tang, Erin Loeliger, M. Summers
- Biology, ChemistryJournal of Molecular Biology
- 11 April 2003
Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein
- Chun Tang, Y. Ndassa, M. Summers
- Biology, ChemistryNature Structural Biology
- 1 July 2002
Comparison of the immature and mature CAN structures reveals that β-hairpin formation induces a ∼2 Å displacement of helix 6 and a concomitant displacement of the cyclophylin-A (CypA)-binding loop, suggesting a possible allosteric mechanism for CypA-mediated destabilization of the capsid particle during infectivity.
Amino Acid Substitutions in Gag Protein at Non-cleavage Sites Are Indispensable for the Development of a High Multitude of HIV-1 Resistance against Protease Inhibitors*
- H. Gatanaga, Yasuhiro Suzuki, H. Mitsuya
- BiologyJournal of Biological Chemistry
- 22 February 2002
It is strongly suggested that non-cleavage site amino acid substitutions in the Gag protein recover the reduced replicative fitness of HIV-1 caused by mutations in the viral protease and may open a new avenue for designing PIs that resist the emergence of PI-resistant HIV- 1.
Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease
- Chun Tang, J. Louis, Annie Aniana, J. Suh, G. Clore
- Biology, ChemistryNature
- 2 October 2008
Using paramagnetic relaxation enhancement, a technique that is exquisitely sensitive to the presence of minor species, it is shown that the mini-precursor forms highly transient, lowly populated (3–5%) dimeric encounter complexes that involve the mature dimer interface but occupy a wide range of subunit orientations relative to the matureDimer.
Structure of the N-terminal 283-Residue Fragment of the HIV-1 Gag Polyprotein
- Chun Tang, Y. Ndassa, M. Summers
- Biology
- 26 June 2002
Antimicrobial constituents from the tubers of Bletilla ochracea.
- Xinzhou Yang, Chun Tang, Ping Zhao, G. Shu, Zhinan Mei
- ChemistryPlanta Medica
- 1 March 2012
Phenanthrenes exhibited antibacterial activities against gram-positive bacteria Staphylococcus aureus, S. epidermidis, and Bacillus subtilis, with MIC values of 12.5-25 µg/mL.
A New Noroleanane from the Seeds of Trichosanthes kirilowii
A new noroleanane named as karounitriol (1), together with four known compounds, 7-oxodihydrokarounidiol (2), isokarounidiol (3), karounidiol (4), and stigmasta-7,22-dien-3β-ol were isolated from the…
HIV-1 Myristoylated Matrix
- Chun Tang, Erin Loeliger, P. Luncsford, I. Kinde, D. Beckett, M. Summers
- Chemistry
- 8 January 2004
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