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Tolerability, Gut Effects, and Pharmacokinetics of Methylnaltrexone Following Repeated Intravenous Administration in Humans
Previous studies have shown that a single dose of methylnaltrexone, a unique peripheral opioid antagonist, reverses opioid‐induced gut hypomotility in humans. Because repeated drug doses are likelyExpand
The Gamma-Aminobutyric Acidergic Effects of Valerian and Valerenic Acid on Rat Brainstem Neuronal Activity
Valerian is a medicinal herb that produces anxiolytic and sedative effects. It was suggested that valerian acts via gamma-aminobutyric acid (GABA)ergic mechanisms. Previous studies showed binding ofExpand
Component analysis and target cell-based neuroactivity screening of Panax ginseng by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.
Ginseng is one of the most widely used natural medicines in the world. Recent studies have suggested Panax ginseng has a wide range of beneficial effects on aging, central nervous system disorders,Expand
Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: Comparison between white and red ginseng
Previous studies showed that Asian ginseng, Panax ginseng C.A. Meyer, may have anti-cancer properties. However, there is limited data exploring the use of Asian ginseng as an adjuvant toExpand
Herbal medicines and perioperative care.
ContextWidespread use of herbal medications among the presurgical population may have a negative impact on perioperative patient care.ObjectivesTo review the literature on commonly used herbalExpand
Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
American ginseng is a commonly consumed herbal medicine in the United States and other countries. Ginseng saponins are considered to be its active constituents. We have previously demonstrated in anExpand
Role of saffron and its constituents on cancer chemoprevention
Abstract Context: Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of aExpand
Clinical Pain Management: Cancer Pain
Find the secret to improve the quality of life by reading this clinical pain management cancer pain. This is a kind of book that you need now. Besides, it can be your favorite book to read afterExpand
Improving anticancer activities of Oplopanax horridus root bark extract by removing water‐soluble components
O. horridus is used as a folk medicine by natives in the Northern Pacific coast of North America. This experiment studied the antiproliferative effects of the extract of O. horridus root bark and itsExpand
Monocyclic monoterpenes as penetration enhancers of ligustrazine hydrochloride for dermal delivery
Abstract The purpose of this study was to explore the enhancing effects and the mechanism of monocyclic monoterpene penetration enhancers (menthol and menthone) on the transdermal absorption ofExpand