• Publications
  • Influence
Structure and Mechanism of Helicobacter pylori Fucosyltransferase
A catalytic mechanism and a model of polysaccharide binding are proposed not only to explain the observed variations in H. pylori lipopolysaccharides, but also to facilitate the development of potent inhibitors. Expand
Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents.
It is demonstrated that 1-3, and 7 have anti-inflammatory effects and 5, 6, and 12 are potential anti- inflammation and cancer chemopreventive agents. Expand
Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis.
The potent inhibitory effect of compound 11 on NO production in lipopolysaccharide (LPS)-activated macrophages, probably through the suppression of iNOS protein expression, is illustrated. Expand
Xanthine oxidase inhibitory triterpenoid and phloroglucinol from guttiferaceous plants inhibit growth and induced apoptosis in human NTUB1 cells through a ROS-dependent mechanism.
Flow cytometric analysis indicated that treatment of NTUB1 with 1 or 1 cotreated with cisplatin led to the cell cycle arrest, accompanied by an increase in the extent of apoptotic cell death, which suggested that the presentation of cell cycle arrests and apoptosis was mediated through an increased amount of ROS. Expand
Structure-activity relationship studies on chalcone derivatives. the potent inhibition of chemical mediators release.
The potent inhibitory effect of 2',5'-dihydroxy- dihydrochaclones on NO production in LPS-activated macrophages and microglial cells is proposed to be useful for the relief of septic shock. Expand
Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.
The antitumor mechanism of morusin in HT-29 cells may be via activation of caspases and inhibition of NF-kappaB, and downregulation in the expression of Ku70 and XIAP was exhibited afterward. Expand
Flavonoids from Artocarpus heterophyllus
Abstract A new flavonone, a new prenylflavone, a novel phenolic compound, heterophylol, reported in a previous paper, and nine known flavonoids have been isolated from the root of ArtocarpusExpand
Phenolics from Hypericum geminiflorum
Abstract Five new constituents were isolated from the heartwood and roots of Hypericum geminiflorum. The structures were characterized as (2R,3R)-3,5,7,2′,5′-pentahydroxyflavan, 3,5-Expand
Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans
Flavonoids, 1, 5, 6, 7, and 8 may block the gate of the active site of COX-1 and interfere the conversion of arachidonic acid to prostaglandin (PG) H2 in the COx-1 active site. Expand
Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species.
Flow cytometric analysis exhibited that treatment of NTUB1 with 5 or 17 or 23 led to the cell cycle arrest accompanied by an increase in apoptotic cell death after 24 or 48 h, and data suggest that the presentation of G1 phase arrest and apoptosis in 5- and 23-treatedNTUB1 for 24 h mediated through increased amount of ROS in cells exposed with 5 and 23, respectively. Expand