Chun Nan Chen

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DNA comprising 219 447 bp was sequenced in nine cosmids and verified at > 99.9% precision. Of the standard repetitive elements, 187 Alus make up 20.6% of the sequence, but there were only 27 MERs (2.9%) and 17 L1 fragments (1.6%). This may be characteristic of such high GC (57%) regions. The sequence also includes an 11.3 kb tract duplicated with 99.2%(More)
GPC3, the gene modified in the Simpson-Golabi-Behmel gigantism/overgrowth syndrome (SGBS), is shown to span more than 500 kb of genomic sequence, with the transcript beginning 197 bp 5' of the translational start site. The Xq26.1 region containing GPC3 as the only known gene has been extended to > 900 kb by sequence analysis of flanking BAC clones. Two GC(More)
Ordered shotgun sequencing (OSS) has been successfully carried out with an Xq25 YAC substrate. yWXD703 DNA was subcloned into lambda phage and sequences of insert ends of the lambda subclones were used to generate a map to select a minimum tiling path of clones to be completely sequenced. The sequence of 135 038 nt contains the entire ANT2 cDNA as well as(More)
Recently, we have shown that mutations in the X-linked glypican 3 (GPC3) gene cause the Simpson-Golabi-Behmel overgrowth syndrome (SGBS; ). The next centromeric gene detected is another glypican, glypican 4 (GPC4), with its 5' end 120763bp downstream of the 3' terminus of GPC3. One recovered GPC4 cDNA with an open reading frame of 1668nt encodes a putative(More)
a Department of Electronic Engineering, Far East University of Technology, Tainan 744, Taiwan b Departmnet of Mechanics, National Chin-Yi University of Technology, Taichung 411, Taiwan c Department of Mechanical Engineering, Chinese Military Academy, Fengshan 83059, Taiwan d Graduate Institute of Precision Manufacturing, National Chin-Yi University of(More)
The Editors and publisher gratefully acknowledge the excellent work performed by our reviewers. The quality of a journal is definitely depending on the review process. The work laid down by our reviewers is essential for the increasing interest of our journal within ORL-HNS in Europe and outside. We are sure that we have a common interest to make European(More)
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