Chun Ji Yin

Learn More
Low selectivity is one of the major problems of currently used anticancer drugs, therefore, there is a high demand for novel, selective antitumor agents. In this study, the anticancer effects and mechanisms of guttiferone K (GUTK), a novel polyprenylated acylphloroglucinol derivative isolated from Garcinia cowa Roxb., were examined for its development as a(More)
Three new indole alkaloids, named kopsihainins A-C (1-3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a(More)
A simple, rapid, sensitive and selective liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of azithromycin in rabbit conjunctiva tissues using roxithromycin as internal standard. Following a deproteinization procedure, the samples were eluted isocratically at a flow rate of 0.3mL/min utilizing a mobile(More)
Drug release simultaneously with carrier decomposition has been demonstrated in SiO2-drug composite nanoparticles. By creating a radial drug concentration gradient in the nanoparticle, controllable release of the drug is primarily driven by diffusion. Escape of the drug molecules then triggers the SiO2 carrier decomposition, which starts from the center of(More)
The photosensitizer (PS) methylene blue (MB) is confined in the close vicinity of an Au nanorod, by incorporating it into SiO2 during Au-core/SiO2-shell nanoparticle (NP) growth. Upon light irradiation of the Au@(SiO2-MB) NPs, generation of reactive oxygen species and their transport to the cytoplasm are directly responsible for significantly decreased cell(More)
A new polyoxypregnane aglycone, tenacigenin D (1), and seven new C21 steroid glycosides, tenacissimosides D-J (2-8), were isolated from the stems of Marsdenia tenacissima. Their structures were determined by interpretation of their 1D and 2D NMR and other spectroscopic data, as well as by comparison with published values for related known compounds.(More)
ETHNOPHARMACOLOGICAL RELEVANCE Multidrug resistance (MDR) of cancer is often associated with the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), multidrug resistance-associated protein-1 (MRP-1) and breast cancer resistance protein (BCRP or ABCG2), in cancer cells, which facilitates the active efflux of a wide(More)
α-Aminoxy peptide AxyP1 has been reported to form synthetic chloride channel in living cells, thus it may have therapeutic potential for the treatment of diseases associated with chloride channel dysfunction. However, this study revealed significant gastrointestinal (GI) instability and extensive hepatic metabolism of AxyP1. To improve its GI and metabolic(More)
Arctic microalgae are considered alternative sources for biodiesel production in cold climates. In this study, we describe the isolation of a novel Chlamydomonas sp. from Arctic sea ice, which we named ArM0029A, and the development of a new culture medium, HAP3, that allows greater cell growth and density than seawater-based media. The fatty acid(More)
Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure of berberine (the major active compound) in the Coptidis(More)