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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
TLDR
It is suggested that inhibiting the IL-1R–Myd88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens. Expand
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
TLDR
It is found that the Toll/IL-1R (TIR) signal transduction adaptor myeloid differentiation primary response protein 88 (MyD88) is required for acute gouty inflammation and that the requirement of MyD88 in this process is primarily through its function as an adaptor molecule in the IL-1 R signaling pathway. Expand
Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal
TLDR
It is shown that expressed coronavirus envelope protein M specifically interacted with coexpressed noncoronavirus RNA transcripts containing the short viral packaging signal in the absence of coronav virus N protein, and this M protein-packaging signal interaction led to specific packaging of the packaging signal-containing RNA transcripts into coronvirus-like particles in the presence of N protein. Expand
Uric acid promotes an acute inflammatory response to sterile cell death in mice.
TLDR
It is found that uric acid depletion substantially reduces the cell death-induced inflammatory response and is identified as a proinflammatory molecule released from dying cells that contributes significantly to the cellDeath-inducedinflammatory responses in vivo. Expand
Murine Coronavirus Replication Induces Cell Cycle Arrest in G0/G1 Phase
TLDR
Mouse hepatitis virus replication in actively growing DBT and 17Cl-1 cells resulted in the inhibition of host cellular DNA synthesis and the accumulation of infected cells in the G0/G1 phase of the cell cycle, and a reduction in the amounts of G1 cyclin-Cdk complexes in MHV-infected cells led to inhibited cell cycle progression through late G1 and into the S phase. Expand
Bacterial infection in association with snakebite: a 10-year experience in a northern Taiwan medical center.
TLDR
Cobra bite causes more severe bacterial infection than other kinds of snakebites and oral amoxicillin/clavulanate plus ciprofloxacin or parenteral piperacillin/tazobactam alone can be the choices for empirical or definitive treatment, and surgical intervention should be considered for established invasive soft tissue infections. Expand
Natural endogenous adjuvants
TLDR
It has been postulated that in some circumstances where immune responses are generated in the apparent absence of any microbial or other exogenous adjuvant, the danger signals come from endogenous adjuvants that are released from dying cells. Expand
Murine Coronavirus Nonstructural Protein p28 Arrests Cell Cycle in G0/G1 Phase
TLDR
The present data suggest the following model of p28-induced G0/G1 cell cycle arrest, which suggests that p28 expression increased p53 stability and that p21Cip1 was transcriptionally activated in a p53-dependent manner. Expand
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.
TLDR
Findings suggest a mechanism of cytotoxic action of YC-1 and indicate that YC -1 may be a promising chemotherapy agent against lung cancer. Expand
Gray-scale liver enhancement with Sonazoid (NC100100), a novel ultrasound contrast agent; detection of hepatic tumors in a rabbit model.
TLDR
Sonazoid might be useful for the detection of undifferentiated tumors in the liver by making it possible to visualize neovascularity in the early phase and clear contrast defects in the delayed phase, not only in the harmonic but also in the conventional mode. Expand
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