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MOTIVATION Microarrays are capable of determining the expression levels of thousands of genes simultaneously. One important application of gene expression data is classification of samples into categories. In combination with classification methods, this technology can be useful to support clinical management decisions for individual patients, e.g. in(More)
A reliable and accurate identification of the type of tumors is crucial to the proper treatment of cancers. In recent years, it has been shown that sparse representation (SR) by l_1-norm minimization is robust to noise, outliers and even incomplete measurements, and SR has been successfully used for classification. This paper presents a new SR-based method(More)
Tumor clustering is becoming a powerful method in cancer class discovery. Nonnegative matrix factorization (NMF) has shown advantages over other conventional clustering techniques. Nonetheless, there is still considerable room for improving the performance of NMF. To this end, in this paper, gene selection and explicitly enforcing sparseness are introduced(More)
This paper proposes a novel and successful method for recognizing palmprint based on radial basis probabilistic neural network (RBPNN) proposed by us. The RBPNN is trained by the orthogonal least square (OLS) algorithm and its structure is optimized by the recursive OLS algorithm (ROLSA). The Hong Kong Polytechnic University (PolyU) palmprint database,(More)
How to identify a set of genes that are relevant to a key biological process is an important issue in current molecular biology. In this paper, we propose a novel method to discover differentially expressed genes based on robust principal component analysis (RPCA). In our method, we treat the differentially and non-differentially expressed genes as(More)
Identifying protein-protein interactions (PPIs) is essential for elucidating protein functions and understanding the molecular mechanisms inside the cell. However, the experimental methods for detecting PPIs are both time-consuming and expensive. Therefore, computational prediction of protein interactions are becoming increasingly popular, which can provide(More)