Learn More
In citation network analysis, complex behavior is reduced to a simple edge, namely, node A cites node B. The implicit assumption is that A is giving credit to, or acknowledging, B. It is also the case that the contributions of all citations are treated equally, even though some citations appear multiply in a text and others appear only once. In this (More)
Serum response factor (SRF) is a ubiquitously expressed transcription factor that regulates cell-specific functions such as muscle development and breast cancer metastasis. The myocardin-related transcription factors (MRTFs), which are transcriptional coactivators mediating cell-specific functions of SRF, are also ubiquitously expressed. How MRTFs and SRF(More)
In this article, we use innovative full-text citation analysis along with supervised topic modeling and networkanalysis algorithms to enhance classical bibliometric analysis and publication/author/venue ranking. By utilizing citation contexts extracted from a large number of full-text publications, each citation or publication is represented by a(More)
Online music streaming services (MSS) experienced exponential growth over the past decade. The giant MSS providers not only built massive music collection with metadata, they also accumulated large amount of heterogeneous data generated from users, e.g. listening history, comment, bookmark, and user generated playlist. While various kinds of user data can(More)
Repression of peroxisome proliferator-activated receptor γ (PPARγ)-dependent transcription by the nuclear receptor corepressor (NCoR) is important for homeostatic expression of PPARγ target genes in vivo. The current model states that NCoR-mediated repression requires its direct interaction with PPARγ in the repressive conformation. Previous studies,(More)
E proteins are a family of helix-loop-helix transcription factors that play important roles in cell differentiation and homeostasis. They contain at least two activation domains, AD1 and AD2. ETO family proteins and the leukemogenic AML1-ETO fusion protein are corepressors of E proteins. It is thought that ETO represses E-protein activity by interacting(More)
Nuclear receptor corepressor (NCoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) function as corepressors for diverse transcription factors including nuclear receptors such as estrogen receptors and androgen receptors. Deregulated functions of NCoR and SMRT have been observed in many types of cancers and leukemias. NCoR and SMRT(More)
Up to 15% of acute myeloid leukemias (AMLs) are characterized by the abnormal expression of the eight-twenty-one (ETO) transcriptional corepressor within an AML1-ETO fusion protein. The t(8;21) chromosomal translocation serves not only to disrupt WT AML1 function but also to introduce ETO activity during hematopoiesis. AML1-ETO was recently shown to inhibit(More)
The sheer volume of scholarly publications available online significantly challenges how scholars retrieve the new information available and locate the candidate reference papers. While classical text retrieval and pseudo relevance feedback (PRF) algorithms can assist scholars in accessing needed publications, in this study, we propose an innovative(More)