Chun Chun Wang

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To characterize fibroblast growth factor (FGF) gene expression in the late fetal (days E18 to E22) and early postnatal lung (days P0 to P28), when the alveolar region undergoes extensive growth and reorganization, we analyzed the expression of four FGF receptors and six ligands. FGF receptor 1 (FGFR1) RNA levels were first low (E18) before rising late in(More)
The disposition of 13-cis- and all- trans-retinoic acids and N-hydroxyethylretinamide has been studied in mice after an intravenous dose of 10 mg/kg. As determined by high-ressure liquid chromatography, serum levels of 13-cis-retinoic acid, in a distribution phase, decreased rapidly over a 30-min period. This was followed by an apparently exponential phase(More)
Alveolar-capillary membrane remodeling, including microvessel wall thickening and interstitial fibrosis, is a well-known sequela of cell proliferation in the hyperoxia-injured lung. The array of growth molecules released locally that potentially mediate this response, and their cell(s) of origin, are currently being defined. To elucidate the role of tumor(More)
The growth factors that operate while the lung remodels in hyperoxia are not known. At the lung periphery, high oxygen levels cause cell hypertrophy and hyperplasia, and this results in a thickening of the alveolar-capillary membrane and the walls of its associated microvessels. The present study examines gene expression of platelet-derived growth factor(More)