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This paper deals with e-tourism, innovation and growth. The Internet is revolutionising the distribution of tourism information and sales. The Korean small and medium-sized tourism enterprises (SMTEs) with well-developed and innovative Web sites can now have " equal Internet access " to international tourism markets. This paper examines problems and(More)
We have recently reported that β-caryophyllene oxide (CPO) can induce apoptosis, suppress tumor growth, and inhibit metastasis through the suppression of signal transducer and activator of transcription 3, PI3K/AKT/mTOR/S6K1 signaling cascades and ROS-mediated MAPKs activation. In the present study, we found that CPO potentiated the apoptosis induced by(More)
  • Jong Hyun Lee, Chulwon Kim, +6 authors Kwang Seok Ahn
  • 2017
Persistent STAT3 activation is seen in many tumor cells and promotes malignant transformation. Here, we investigated whether capsazepine (Capz), a synthetic analogue of capsaicin, exerts anticancer effects by inhibiting STAT3 activation in prostate cancer cells. Capz inhibited both constitutive and induced STAT3 activation in human prostate carcinoma cells.(More)
Persistent phosphorylation of signal transducers and activators of transcription 3 (STAT3) is frequently observed in tumor cells. We found that brassinin (BSN) suppressed both constitutive and IL-6-inducible STAT3 activation in lung cancer cells. Moreover, BSN induced PIAS-3 protein and mRNA, whereas the expression of SOCS-3 was reduced. Knockdown of PIAS-3(More)
Artesunate (ART), a semi-synthetic derivative of artemisinin, is one of the most commonly used anti-malarial drugs. Also, ART possesses anticancer potential albeit through incompletely understood molecular mechanism(s). Here, the effect of ART on various protein kinases, associated gene products, cellular response, and apoptosis was investigated. The in(More)
The paper develops a model of destination competitiveness that will enable comparison between countries and between tourism sector industries. The model seeks to capture the main elements of competitiveness highlighted in the general literature, while appreciating the special issues involved in exploring the notion of destination competitiveness as(More)
Ginkgolic acid C 17:1 (GAC 17:1) extracted from Ginkgo biloba leaves, has been previously reported to exhibit diverse antitumor effect(s) through modulation of several molecular targets in tumor cells, however the detailed mechanism(s) of its actions still remains to be elucidated. Signal transducer and activator of transcription 3 (STAT3) is an oncogenic(More)
Although melittin, a water-soluble 26-amino acid peptide derived from bee venom of Apis mellifera, is known to exert anti-proliferative effects on various tumor cell lines, very little is known about its potential molecular mechanism(s) of action. In the present study, we investigated the effects of melittin on the AKT/mTOR/S6K1/4E-BP1 activation,(More)
The utilization of Information Technology (IT) is spreading in tourism industry with explosive growth of Internet, Social Network Service (SNS) through smart phone applications. Especially, since intensive information has high value on tourism area, IT is becoming a crucial factor in the tourism industry. The smart tourism is explained as an holistic(More)
The common soft keyboard on touchscreens for numerous emerging smart devices requires users to look repeatedly at their fingertip locations. To reduce this visual dependency on size-restricted touchscreens, chorded keyboards have been restudied recently. However, one of their intrinsic problems, learning difficulty, limits their widespread use. Here, we(More)
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