Chukwuemeka R. Nwokocha

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Garcinia kola is regarded as an antidote and anti-hepatotoxic agent. We examined its protection ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver. The ground seed was mixed with rat feed (5%, w/w) and fed to rats while Hg (10 ppm), Cd (200 ppm) and Pb (100 ppm) was given in drinking water. Garcinia kola was administered(More)
OBJECTIVE In this study, we have examined the possibility that there is altered vascular reactivity due to the direct interaction between parasitized erythrocytes and vascular endothelial cells. METHOD Ring preparations of rat aorta were studied using standard in vitro techniques, the rings were mounted in 20 ml organ baths containing PSS under an initial(More)
OBJECTIVE Adherence of erythrocytes infected with Plasmodium falciparum (P falciparum) to microvascular endothelial cells (sequestration) is considered to play an important role in parasite virulence and pathogenesis. In this study, we have examined the possibility that there is altered vascular reactivity due to the direct interaction between the(More)
OBJECTIVES Gongronema latifolium leaves have been used in folklore medicine to manage diabetes mellitus and alleviate dyspepsia. This study aimed to provide a pharmacological basis to the medicinal use ofGongronema latifolium as an antidiabetic and antiulcerogenic agent in diabetes mellitus. METHODS Ethanol extract from the leaf (200 mg/kg bodyweight) of(More)
The effect of vitamin C administration on gastric acid secretion and ulcer in diabetic rats was studied. Vitamin C (200 mg/kg b.w.) was administered to both streptozotocin-induced diabetic and control groups orally for 28 days. Gastric acid secretion was measured and ulcer was induced using ethanol. Histological changes were observed in the stomach. Basal(More)
CONTEXT Zingiber officinale (Zingiberaceae) is a herb used for culinary and therapeutic purposes due to its anti-inflammatory and antioxidant potentials. OBJECTIVES We examined its protective ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver. MATERIALS #ENTITYSTARTX00026; METHODS Ground Zingiber officinale (7%, w/w of(More)
CONTEXT Palm oil from Elaeis guineensis is an edible nutrient substance with anti-inflammatory and antioxidant properties. We examined its protective effect against lead (Pb) and cadmium (Cd) accumulation in the liver. MATERIALS AND METHODS 12% w/w of palm oil (PO) in rat chow concentrate was fed to rats exposed to Cd (200ppm) and Pb (100ppm) in drinking(More)
The resultant effects of cadmium exposure are seen in almost all the systems of the body, however, this study is designed to quantify its accumulation in tissues of animals exposed to cadmium. The rats were divided into two distinct groups of males and females, which were then divided into three groups, each for the monitoring of exposure. Group 1 served as(More)
OBJECTIVE Malaria causes more deaths worldwide than any other parasitic disease. Many aspects of the biology that governs the pathogenesis of this parasite are still unclear. Therefore insight into the complexity of the pathogenesis of malaria is vital to understand the disease, particularly as it relates to blood pressure. METHODS In vivo and in vitro(More)
Apocynin is reported to have antioxidant and NADPH oxidase inhibitor activities. Cadmium toxicity is reported to causes oxidative damage, resulting in vascular dysfunction, reduced bioavailability of nitric oxide (NO) and hypertension. The study aimed to investigate the protective effects of apocynin in cadmium-induced hypertension. Thirty-six (36) adult(More)