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6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.
A mechanistic evaluation showed that 2-R potently inhibited cell growth and colony formation, which is associated with a delay in S phase progression through the inhibition of DNA synthesis, which will facilitate the discovery of new Phenanthroindolizidine and phenanthroquinolIZidine alkaloids for use as anticancer drug candidates.
Discovery and SARs of Trans-3-Aryl Acrylic Acids and Their Analogs as Novel Anti- Tobacco Mosaic Virus (TMV) Agents
These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of glycoconjugates of phenanthroindolizidines alkaloids
Glycoconjugates of phenanthroindolizidine alkaloids targeting tobacco mosaic virus (TMV) RNA displayed significant higher activity than commercial ningnanmycin, and thus could be considered for novel therapy against plant virus infection.
4-(Dimethylamino)pyridine-catalysed iodolactonisation of γ,δ-unsaturated carboxylic acids.
4-(Dimethylamino)pyridine functioned as an excellent catalyst for iodolactonisation reactions of γ,δ-unsaturated carboxylic acids, affording γ-lactones, δ-lactones, or both under neutral conditions
4‐(Dimethylamino)pyridine‐Catalyzed Iodolactonisation of γ,δ‐Unsaturated Carboxylic Acids.
Whereas γ-substituted γ,δ-unsaturated carboxylic acids form γ-lactones as the only isolable product, δ-substituted γ,δ-unsaturated carboxylic acids form either γ-lactones or δ-lactones or mixtures