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Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory
TLDR
It is suggested that PGS32 can improve hippocampus-dependent learning and memory, possibly through improvement of synaptic transmission, activation of the MAP kinase cascade and enhancement of the level of BDNF.
Carbazole alkaloids from the stems of Clausena lansium.
TLDR
Screening results indicated that compounds 1, 6, 8-10, 13, 14, and 17 showed selective neuroprotective effects at the concentration of 10 μM.
Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia.
TLDR
Screening results indicated that compounds 1 - 16 showed neuroprotective effects against serum deficiency and glutamate at the concentration of 10 (-5) mol/L, and six new triterpenoid saponins were isolated.
Bioactive 18(4 → 3)-abeo-abietanoid derivatives from the leaves of Tripterygium wilfordii
Tripterlides A–F (1–6), six new abietane diterpenoid derivatives, together with six known abietane diterpenoids (7–12) were obtained from the leaves of Tripterygium wilfordii. Tripterlides A–C (1–3)
Anti-inflammatory sesquiterpene derivatives from the leaves of Tripterygium wilfordii.
TLDR
In an in vitro bioassay, compounds 1, 9, 11, 13, 14, and 18 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages at 5 μM; all compounds were inactive when tested against five human cancer cell lines.
Guajavadimer A, a Dimeric Caryophyllene-Derived Meroterpenoid with a New Carbon Skeleton from the Leaves of Psidium guajava.
TLDR
Guajavadimer A showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells and its structure and absolute configuration were elucidated on the basis of spectroscopic data and X-ray crystallography.
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