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Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies.
Hematologic malignancies provide a suitable testing environment for cell-based immunotherapies, which were pioneered by the development of allogeneic hematopoietic stem cell transplant. All types ofExpand
Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies
CAR T-cell antitumor therapy fails when the tumor loses expression of the chosen epitope. Receptors that mimic antibodies and that recognize two epitopes may reduce the chances for tumor cells toExpand
Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling
  • Y. Yu, S. Gu, +16 authors Xinhua Feng
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 5 September 2017
Significance TGF-β and related growth factors critically regulate cell potency and functions. Smad7 is induced by TGF-βs and inhibits the physiological functions of TGF-β signaling. This studyExpand
Smoking and COX-2 Functional Polymorphisms Interact to Increase the Risk of Gastric Cardia Adenocarcinoma in Chinese Population
Background Over-expression and increased activity of cyclooxygenase (COX)-2 induced by smoking has been implicated in the development of cancer. This study aimed to explore the interaction betweenExpand
Performance of a Novel Blood-Based Early Colorectal Cancer Screening Assay in Remaining Serum after the Blood Biochemical Test
Background Combination of multiple biomarkers was an effective strategy to improve sensitivity in cancer diagnosis and screening. However, the performance of the combination of methylated SEPT9 andExpand
STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates transformingExpand
Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily of structurally related signaling proteins that regulate a wide array of cellular functions. The key step in BMP signal transductionExpand
Phosphatase UBLCP1 controls proteasome assembly
Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1), an FCP/SCP phosphatase family member, was identified as the first proteasome phosphatase. UBLCP1 binds to proteasome subunitExpand
Regulation of p27Kip1 phosphorylation and G1 cell cycle progression by protein phosphatase PPM1G.
The cell cycle, an essential process leading to the cell division, is stringently controlled by the key cell cycle regulators, cyclin-CDK complexes, whose activity is further regulated by a varietyExpand
Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells
Immunotherapy has emerged as a promising strategy for the treatment of metastatic melanoma. Clinical studies have demonstrated the feasibility of cancer immunotherapy using tumor antigens recognizedExpand