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PURPOSE To assess the possibility of using CYP2D6 10 +/- CYP3A5*3 as biomarkers to predict the pharmacokinetics of diltiazem and its two metabolites among healthy Chinese subjects. METHODS 41 healthy Chinese were genotyped for CYP3A5 3 and CYP2D6 10, and then received a single oral dose of diltiazem hydrochloride capsules (300 mg). Multiple blood samples(More)
BACKGROUND This study aimed to evaluate the effects of noninvasive acupoint stimulation therapy with middle-frequency electrical waves on dysmenorrhea in young women. METHODS This randomized controlled trial enrolled 66 gynecology patients who had primary dysmenorrhea, which was defined as painful menstruation without pelvic pathology (secondary(More)
PROBLEM/OBJECTIVE Laser-assisted lithotripsy under sialendoscopy has the potential to overcome the limitations of traditional sialendoscopic lithotripsy when facing salivary stones. In this preliminary study, we report our experience with Holmium:YAG laser-assisted lithotripsy. METHODS Data from 11 Asian patients receiving sialendoscopies for(More)
Objective: To investigate the alternations of surface antigens of leukocytes after severe injury and the correlation with clinical outcome. Setting: Emergency Department and Intensive Care Unit of a university hospital. Patients: Patients with severe trauma (injury severity score >16) were enrolled. Those who were transferred or had critical injuries were(More)
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