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Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ∼500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome isExpand
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Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey
Bile salt synthesis is a specialized liver function in vertebrates. Bile salts play diverse roles in digestion and signaling, and their homeostasis is maintained by controlling input (biosynthesis)Expand
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A thermogenic secondary sexual character in male sea lamprey
SUMMARY Secondary sexual characters in animals are exaggerated ornaments or weapons for intrasexual competition. Unexpectedly, we found that a male secondary sexual character in sea lampreyExpand
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The Sea Lamprey as an Etiological Model for Biliary Atresia
Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most commonExpand
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An UPLC-MS/MS method for quantitative profiling of bile acids in sea lamprey plasma and tissues.
Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due toExpand
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Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey
BackgroundLampreys are extant representatives of the jawless vertebrate lineage that diverged from jawed vertebrates around 500 million years ago. Lamprey genomes contain information crucial forExpand
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Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis
BackgroundBiliary atresia (BA) is a human infant disease with inflammatory fibrous obstructions in the bile ducts and is the most common cause for pediatric liver transplantation. In contrast, theExpand
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Evolutionarily adaptive mechanisms to biliary atresia in the sea lamprey
EVOLUTIONARILY ADAPTIVE MECHANISMS TO BILIARY ATRESIA IN THE SEA LAMPREY By Chu-Yin Yeh Lamprey species appeared over 500 million years and are therefore important evolutionary models for researchExpand
TGF‐β Signaling Plays a Pivotal Role During Developmental Biliary Atresia in Sea Lamprey (Petromyzon marinus)
Biliary atresia (BA) is a rare neonatal disease with unknown causes. Approximately 10% of BA cases develop in utero with other congenital defects that span a large spectrum of disease variations,Expand