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  • Chrystelle Brignone, Maya Gutierrez, +9 authors Frédéric Triebel
  • Medicine
  • Journal of Translational Medicine
  • 2010 (First Publication: 23 July 2010)
  • BackgroundIMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8+ T cell activation. We reportExpand
  • Chrystelle Brignone, Bernard Escudier, Caroline Grygar, Manon Marcu, Frédéric Triebel
  • Medicine
  • Clinical Cancer Research
  • 2009 (First Publication: 1 October 2009)
  • Purpose: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of IMP321, a recombinant soluble LAG-3Ig fusion protein which agonizes MHC class II–driven dendritic cellExpand
  • Chrystelle Brignone, Caroline Grygar, Manon Marcu, Knut Schaekel, Frédéric Triebel
  • Biology, Medicine
  • The Journal of Immunology
  • 2007 (First Publication: 15 September 2007)
  • The principal antitumor immune response is mediated through the activation of type 1 cytotoxic (Tc1) CD8 T cells, NK cells, and monocytes/macrophages. In this study, we investigated the potency of aExpand
  • Chrystelle Brignone, Caroline Grygar, Manon Marcu, Gaëlle Perrin, Frédéric Triebel
  • Medicine
  • Vaccine
  • 2007 (First Publication: 1 June 2007)
  • sLAG-3 (IMP321), a natural high affinity ligand for MHC class II, was tested for safety, tolerability and its ability to increase Th-1-type T cell responses to a commercial trivalent split influenzaExpand
  • Chrystelle Brignone, Caroline Grygar, Manon Marcu, Gaëlle Perrin, Frédéric Triebel
  • Medicine
  • Journal of immune based therapies and vaccines
  • 2007 (First Publication: 29 March 2007)
  • BackgroundLAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-likeExpand
  • François Duhoux, Agnes Jager, +8 authors Frédéric Triebel
  • Medicine
  • 2017 (First Publication: 30 May 2017)
  • 1062Background: IMP321 is a recombinant soluble LAG3-Ig fusion protein that binds to MHC class II molecules and mediates antigen-presenting cell (APC) activation followed by CD8 T-cell activation.Expand
  • O. Zurita Muñoz, Chrystelle Brignone, N Grenier-Brossette, Jean-Yves Bonnefoy, Jean-Louis Cousin
  • The Journal of Biological Chemistry
  • 1998 (First Publication: 27 November 1998)
  • In the present study we have compared the binding of two monoclonal antibodies to CD23, EBVCS1 and mAb25, which recognize the stalk and the lectin domain, respectively, on the CD23 molecule. At 4 °C,Expand