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BACKGROUND There is growing interest in the role of infections in the aetiology of acute myocardial infarction (AMI). We undertook a large, population-based study to explore the association between risk of AMI and recent acute respiratory-tract infection. METHODS We used data from general practices in the UK (General Practice Research Database). Potential(More)
Concern about the risks of cardiovascular illness in women using combined oral contraceptives (OC) containing the progestagens desogestrel and gestodene prompted two studies of data from the UK General Practice Research Database. We compared the risks of certain cardiovascular illnesses in otherwise healthy women exposed to one of three OCs containing < 35(More)
BACKGROUND At the request of researchers in the UK, we conducted a case-control study to explore the relation between use of postmenopausal oestrogen hormone replacement therapy (HRT) and idiopathic venous thromboembolism (VTE). METHODS The study was based on information derived from Group Health Cooperative of Puget Sound for the period 1980 to 1994.(More)
Computer simulation has been employed to evaluate proposed changes in the delivery of health care. However, little is known about the utility of simulation approaches for analysis of changes in the delivery of surgical care. We searched eight bibliographic databases for this comprehensive review of the literature published over the past five decades, and(More)
Computer simulation of patient flow has been used extensively to assess the impacts of changes in the management of surgical care. However, little research is available on the utility of existing modeling techniques. The purpose of this paper is to examine the capacity of Statecharts, a system of graphical specification, for constructing a discrete-event(More)
In this paper we present an approach for applying virtual reality (VR) to the creation of a family of educational environments for young users. The immersive and interactive attributes of VR technology can be a powerful tool for education, allowing the learner to actively participate in the surrounding environment. Our approach is based on constructionism,(More)
BACKGROUND In the United Kingdom, clinical guidelines recommend that services for depression and anxiety should be structured around a stepped care model, where patients receive treatment at different 'steps,' with the intensity of treatment (i.e., the amount and type) increasing at each step if they fail to benefit at previous steps. There are very limited(More)
Conceptual modelling, one of the first stages in a simulation study, is about understanding the situation under study and deciding what and how to model. We argue that stakeholder involvement as part of conceptual modelling could lead to a more successful simulation study with better prospects for implementation. Our work is mainly applied in health care(More)
The rapid increase in the demand for long-term care of elderly people leads to a need for a better understanding of resource use, therefore a better knowledge of the survival patterns. The data necessary to model survival and resource use in long-term care are available, but distributed among different institutions – purchasers of care, e.g. Local(More)