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A GAL4-driver line resource for Drosophila neurobiology.
We established a collection of 7,000 transgenic lines of Drosophila melanogaster. Expression of GAL4 in each line is controlled by a different, defined fragment of genomic DNA that serves as aExpand
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Drosophila Dscam Is Required for Divergent Segregation of Sister Branches and Suppresses Ectopic Bifurcation of Axons
Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaicExpand
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Transmembrane/Juxtamembrane Domain-Dependent Dscam Distribution and Function during Mushroom Body Neuronal Morphogenesis
Besides 19,008 possible ectodomains, Drosophila Dscam contains two alternative transmembrane/juxtamembrane segments, respectively, derived from exon 17.1 and exon 17.2. We wondered whether specificExpand
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Baboon/dSmad2 TGF‐β signaling is required during late larval stage for development of adult‐specific neurons
The intermingling of larval functional neurons with adult‐specific neurons during metamorphosis contributes to the development of the adult Drosophila brain. To better understand this process, weExpand
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Making Drosophila lineage–restricted drivers via patterned recombination in neuroblasts
The Drosophila cerebrum originates from about 100 neuroblasts per hemisphere, with each neuroblast producing a characteristic set of neurons. Neurons from a neuroblast are often so diverse that manyExpand
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Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution
Combining expansion and the lattice light sheet Optical and electron microscopy have made tremendous inroads into understanding the complexity of the brain. Gao et al. introduce an approach forExpand
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Combining Raman Chemical Imaging and Scanning Electron Microscopy to Characterize Ambient Fine Particulate Matter
Raman chemical imaging and scanning electron microscopy (Raman/SEM) have been used in a preliminary study to determine the size, morphology, elemental and molecular composition, and molecularExpand
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Genetic mosaic analysis in the nervous system
Genetic mosaic techniques provide a powerful tool for dissecting gene function in the intricate genetic networks that underlie the formation and function of nervous systems. For instance, it isExpand
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Cortical Column and Whole Brain Imaging of Neural Circuits with Molecular Contrast and Nanoscale Resolution
Optical and electron microscopy have made tremendous inroads in understanding the complexity of the brain, but the former offers insufficient resolution to reveal subcellular details and the latterExpand
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Large Area SEM Backscatter Imaging of GABA Post-Embedding Immunogold, Web-Based Crowdsourcing Segmentation and Local Image Processing for Rigorous Quantification
Large-scale analysis of changes in the amount and localization of molecules in the brain using postembedding immunogold labeling was near to impossible due to spatial constraints of transmissionExpand