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We address issues with the performance of IEEE 802.11, when used in the adhoc mode, in the presence of hidden terminals. We present results illustrating the strong dependence of channel capture behavior on the SNR observed on contending hidden connections. Experimental work has illustrated that in a hidden terminal scenario, the connection having the(More)
In this paper we investigate the performance of common capture models in terms of the fairness properties they reflect across contenting hidden connections. We propose a new capture model, Message Retraining,as a means of providing an accurate description of experimental data. Using two fairness indices we undertake a quantitative study of the accuracy with(More)
— This paper addresses recent experimental measurements from an IEEE 802.11 ad hoc network testbed, which indicate a strong signal strength dependence in the ability of a hidden terminal to gain access to the radio channel. We present analytical results investigating the 'hidden terminal jamming' ability of the IEEE 802.11 DSSS physical layer. Results(More)
This paper addresses experimental measurements from an IEEE 802.11 ad hoc network testbed, which indicate a strong signal strength dependence in the ability of a hidden terminal to gain access to the radio channel. We present analytical results investigating thèhidden terminal jamming' ability of the IEEE 802.11 DSSS physical layer. Results indicate that in(More)
ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this study, we use an ERBB2-transgenic mouse model of breast cancer (neuT) to show that Notch signaling plays a critical role in tumor maintenance. Inhibition of the Notch pathway with a gamma-secretase(More)
Most non-small cell lung cancer (NSCLC) patients harboring activating epidermal growth factor receptor (EGFR) mutations respond to tyrosine kinase inhibitor (TKI) therapy. However, about 30% exhibit primary resistance to EGFR TKI therapy. Here we report that Met protein expression and phosphorylation were associated with primary resistance to EGFR TKI(More)
Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in approximately 30% of patients with advanced mycosis fungoides and Sézary syndrome cutaneous T-cell lymphoma (CTCL). The purpose of this study was to identify biomarkers(More)
Mutations in NOTCH1 are frequently detected in patients with T-cell acute lymphoblastic leukemia (T-ALL) and in mouse T-ALL models. Treatment of mouse or human T-ALL cell lines in vitro with gamma-secretase inhibitors (GSIs) results in growth arrest and/or apoptosis. These studies suggest GSIs as potential therapeutic agents in the treatment of T-ALL. To(More)
Pathways regulating neuronal vulnerability are poorly understood, yet are central to identifying therapeutic targets for degenerative neurological diseases. Here, we characterize mechanisms underlying neurodegeneration in Niemann-Pick type C (NPC) disease, a lysosomal storage disorder characterized by impaired cholesterol trafficking. To date, the relative(More)
Two genetically engineered, conditional mouse models of lung tumor formation, K-ras(LSL-G12D) and K-ras(LSL-G12D)/p53(LSL-R270H), are commonly used to model human lung cancer. Developed by Tyler Jacks and colleagues, these models have been invaluable to study in vivo lung cancer initiation and progression in a genetically and physiologically relevant(More)