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Anti-Müllerian hormone (AMH) and its receptor are involved in the regression of Müllerian ducts in male fetuses. We have now cloned and mapped the human AMH receptor gene and provide genetic proof that it is required for AMH signalling, by identifying a mutation in the AMH receptor in a patient with persistent Müllerian duct syndrome. The mutation destroys(More)
Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV) infection of oligodendrocytes, may develop in patients with immune disorders following reactivation of chronic benign infection. Mutations of JCV capsid viral protein 1 (VP1), the capsid protein involved in binding to sialic acid cell receptors, might(More)
BACKGROUND Progressive multifocal leukoencephalopathy (PML) in natalizumab-treated MS patients is linked to JC virus (JCV) infection. JCV sequence variation and rearrangements influence viral pathogenicity and tropism. To better understand PML development, we analyzed viral DNA sequences in blood, CSF and/or urine of natalizumab-treated PML patients. (More)
BACKGROUND A past history of low trauma fracture is a strong risk factor for future fractures in postmenopausal women and national guidance recommends treatment in the majority of such women AIM To establish the prevalence of bone protective therapy use in postmenopausal women with a history of low trauma fracture Design and METHODS Clinical audit of(More)
Toxoplasma gondii proliferates within host cell vacuoles where the parasite relies on host carbon and nutrients for replication. To assess how T. gondii utilizes these resources, we mapped the carbon metabolism pathways in intracellular and egressed parasite stages. We determined that intracellular T. gondii stages actively catabolize host glucose via a(More)
Both saturated and unsaturated fatty acids (FA) bound to albumin inhibit phytohaemagglutinin (PHA) transformation of human lymphocytes cultured in fetal calf serum (FCS). With two unsaturated FA inhibition is maintained, however, when saturated and unsaturated FA are added simultaneously the inhibition is abolished. When lymphochtes are cultured in human AB(More)
A commercial monoclonal antibody-based enzyme immunoassay (Adenoscreen; Mercia Diagnostics Ltd., Guildford, United Kingdom) for the detection of adenovirus types 40 and 41 in stool specimens was evaluated. Two assay modes were tested. In the first, 177 stool samples were screened for the presence of adenovirus type 40 or 41 (assay mode 1). Virus was(More)
Antigens were prepared from different stages of worm development and adult worm antigens were fractionated by ion exchange and exclusion chromatography. The antigens, or fractions of them, were assessed for their activity in passive haemagglutination reactions or intradermal tests. The results of the passive haemagglutination reactions indicated that(More)
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