Christopher Theisen

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N-cadherin is a transmembrane adhesion receptor that contributes to neuronal development and synapse formation through homophilic interactions that provide structural-adhesive support to contacts between cell membranes. In addition, N-cadherin homotypic binding may initiate cell signaling that regulates neuronal physiology. In this study, we investigated(More)
Anesthesia-related postoperative cognitive dysfunction (POCD) leads to morbidity in the elderly. Lipid peroxidative byproducts (i.e. acrolein) accumulate in aging and may play a role. Sevoflurane, an inhaled anesthetic, sequesters acrolein and enhances the formation of a serotonin-derived melanoid (SDM). SDM may be a biologically relevant polymeric melanoid(More)
Security testing and reviewing efforts are a necessity for software projects, but are time-consuming and expensive to apply. Identifying vulnerable code supports decision-making during all phases of software development. An approach for identifying vulnerable code is to identify its <i>attack surface</i>, the sum of all paths for untrusted data into and out(More)
Security requirements around software systems have become more stringent as society becomes more interconnected via the Internet. New ways of prioritizing security efforts are needed so security professionals can use their time effectively to find security vulnerabilities or prevent them from occurring in the first place. The goal of this work is <i>to help(More)
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and nitrophenylacetate was also examined. Isoflurane(More)
Anesthetic preconditioning occurs when cells previously exposed to inhaled anesthetics are protected against subsequent injury. We hypothesize that inhaled anesthetics may cause slight protein misfolding that involves site-specific dehydration, stimulating cytoprotective mechanisms. Human neuroblastoma cells were exposed to ethanol (as the dehydration(More)
– Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), the glycolytic housekeeping enzyme, exists as an asymmetric tetramer. We previously observed that GAPDH can appear as a dimer and in higher order structures which we proposed may be a decamer. The monomeric subunit contains two rather distinct domains, which are referred to as the nucleotide-binding domain(More)