Christopher Steidle

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BACKGROUND No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation. METHODS We determined the efficacy of dapoxetine in a prospectively predefined integrated analysis of two 12-week randomised, double-blind,(More)
The conversion of testosterone (T) to dihydrotestosterone (DHT) has been demonstrated to be catalysed by at least two isoforms of human steroid 5 alpha-reductase, designated types I and II. Type II 5 alpha-reductase expression predominates in human accessory sex tissues, localized to the fibromuscular stromal compartment. The type I isoform predominates in(More)
Prostatic zonal heterogeneity as a factor influencing urogenital smooth muscle contractile mechanisms was evaluated in the dorsal, lateral, and ventral lobes of the sexually mature rat. Additionally, using the ventral lobe, we assessed the role of the prostatic capsule to determine its contribution to tissue contractility. Smooth muscle contractile(More)
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