Learn More
The design of high-resolution retinal prostheses presents many unique engineering and biological challenges. Ever smaller electrodes must inject enough charge to stimulate nerve cells, within electrochemically safe voltage limits. Stimulation sites should be placed within an electrode diameter from the target cells to prevent 'blurring' and minimize(More)
We present results from luminosity, energy and polarization studies at a future Linear Collider. We compare e + e − and e − e − modes of operation and consider both NLC and TESLA beam parameter specifications at a center-of-mass energy of 500 GeV. Realistic colliding beam distributions are used, which include dynamic effects of the beam transport from the(More)
In laser retinal photocoagulation, short (<20 ms) pulses have been found to reduce thermal damage to the inner retina, decrease treatment time, and minimize pain. However, the safe therapeutic window (defined as the ratio of power for producing a rupture to that of mild coagulation) decreases with shorter exposures. To quantify the extent of retinal heating(More)
PURPOSE Subthreshold retinal phototherapy demonstrated clinical efficacy for the treatment of diabetic macular edema without visible signs of retinal damage. To assess the range of cellular responses to sublethal hyperthermia, expression of the gene encoding a 70 kDa heat shock protein (HSP70) was evaluated after laser irradiation using a transgenic(More)
This study evaluates the effects of exposure duration, beam diameter, and power on the safety, selectivity, and healing of retinal lesions created using a continuous line scanning laser. A 532 nm laser (PASCAL TM) with retinal beam diameters of 40 and 66 µm was applied to 60 eyes of 30 Dutch-Belted rabbits. Retinal exposure duration varied from 15 to 60 µs.(More)
Synchronization of chaotic systems has been studied extensively, and especially, the possible applications to the communication systems motivated many research areas. We demonstrate the effect of the frequency bandwidth limitations in the communication channel on the synchronization of two unidirectionally coupled Mackey-Glass (MG) analog circuits, both(More)
Decreasing the pulse duration helps confine damage, shorten treatment time, and minimize pain during retinal photocoagulation. However, the safe therapeutic window (TW), the ratio of threshold powers for thermomechanical rupture of Bruch's membrane and mild coagulation, also decreases with shorter exposures. Two potential approaches toward increasing TW are(More)
  • 1