Christopher Schuster

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Adequate numbers and functional maturity are needed for leukocytes to exhibit a protective role in host defense. During intrauterine life, the skin immune system has to acquire these prerequisites to protect the newborn from infection in the hostile external environment after birth. We investigated the quantitative, phenotypic, and functional development of(More)
Multipotent mesenchymal stromal cells (MSCs) are found in a variety of adult tissues including human dermis. These MSCs are morphologically similar to bone marrow-derived MSCs, but are of unclear phenotype. To shed light on the characteristics of human dermal MSCs, this study was designed to identify and isolate dermal MSCs by a specific marker expression(More)
The behavior of mobile applications is particularly affected by their execution context, such as location and state a the mobile device. Among other approaches, context-oriented programming can help to achieve context-dependent behavior without sacrificing modularity or adhering to a certain framework or library by enabling fine-grained adaptation of(More)
Human Langerhans cell (LC) precursors populate the epidermis early during prenatal development and thereafter undergo massive proliferation. The prototypic antiproliferative cytokine TGF-β1 is required for LC differentiation from human CD34(+) hematopoietic progenitor cells and blood monocytes in vitro. Similarly, TGF-β1 deficiency results in LC loss in(More)
Antimicrobial peptides and proteins (AMPs) play important roles in skin immune defense due to their capacity to inhibit growth of microbes. During intrauterine life, the skin immune system has to acquire the prerequisites to protect the newborn from infection in the hostile environment after birth, which includes the production of skin AMPs. The aim of this(More)
The adult human skin harbors a variety of leukocytes providing immune surveillance and host defense, but knowledge about their ontogeny is scarce. In this study we investigated the number and phenotype of leukocytes in prenatal human skin (dermal dendritic cells (DDCs), macrophages, T cells (including FoxP3(+) regulatory T cells), and mast cells) to unravel(More)
While types describe what values an expression computes, the effects of an expression describe how it is computed, e.g. whether its evaluation manipulates global state, accesses the file system or may throw certain exceptions. Having to specify types and effects throughout the program might not be feasible in a scripting language but selective, sparse(More)
—Currently, Reflectance Transformation Imaging (RTI) technology is restricted to desktop and high performance computing devices. In recent years, mobile devices and tablets have become ubiquitous due to their increased performance. However, the size of RTI files (≈100 MB) limits the range of portable devices capable of displaying RTI files. In this paper,(More)
Refactoring is a code transformation performed at development time that improves the quality of code while preserving its observable behavior. Macro expansion is also a code transformation, but performed at compile time, that replaces instances of macro invocation patterns with the corresponding macro body or template. The key insight of this paper is that(More)