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Journals and Conferences
The chemokines CCL3 and CCL5, as well as their shared receptor CCR1, are believed to play a role in the pathogenesis of several inflammatory diseases including rheumatoid arthritis, multiple… (More)
Advances in the field of drug discovery have brought an explosion in the quantity of data available to medicinal chemists and other project team members. New strategies and systems are needed to help… (More)
Here we describe the development of novel methods for compound evaluation and prioritization based on the structure-activity relationship matrix (SARM) framework. The SARM data structure allows… (More)
Arising from Kai, F. M., Tyler, S. C., Randerson, J. T. & Blake, D. R. 476, 194–197 (2011)10.1038/nature10259To understand the reasons for global CH4 changes since the 1990s, Kai et al. evaluated a… (More)
The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described.
The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.