Christopher S. Chen

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Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.

Rowena McBeath, Dana M. Pirone, Celeste M. Nelson, Kiran Bhadriraju, Christopher S. Chen
Developmental cell
2004

Commitment of stem cells to different lineages is regulated by many cues in the local tissue microenvironment. Here we demonstrate that cell shape regulates commitment of human mesenchymal stem cells… (More)

Cells lying on a bed of microneedles: an approach to isolate mechanical force.

J. L. Tan, J. K. Tien, Dana M. Pirone, Darren S Gray, Kiran Bhadriraju, Christopher S. Chen
Proceedings of the National Academy of Sciences…
2003

We describe an approach to manipulate and measure mechanical interactions between cells and their underlying substrates by using microfabricated arrays of elastomeric, microneedle-like posts. By… (More)

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

Carsten Grashoff, Brenton D Hoffman, +8 authors Martin A Schwartz
Nature
2010

Mechanical forces are central to developmental, physiological and pathological processes. However, limited understanding of force transmission within sub-cellular structures is a major obstacle to… (More)

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure.

Andrew Maniotis, Christopher S. Chen, Donald E. Ingber
Proceedings of the National Academy of Sciences…
1997

We report here that living cells and nuclei are hard-wired such that a mechanical tug on cell surface receptors can immediately change the organization of molecular assemblies in the cytoplasm and… (More)

Mechanical tugging force regulates the size of cell-cell junctions.

Zhijun Liu, J. L. Tan, +5 authors Christopher S. Chen
Proceedings of the National Academy of Sciences…
2010

Actomyosin contractility affects cellular organization within tissues in part through the generation of mechanical forces at sites of cell-matrix and cell-cell contact. While increased mechanical… (More)

Control of stem cell fate by physical interactions with the extracellular matrix.

Farshid Guilak, Daniel M. Cohen, Bradley T. Estes, Jeffrey M. Gimble, Wolfgang B Liedtke, Christopher S. Chen
Cell stem cell
2009

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem… (More)

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

Jianping Fu, Yang-Kao Wang, +4 authors Christopher S. Chen
Nature Methods
2010

We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We… (More)

Emergent patterns of growth controlled by multicellular form and mechanics.

Celeste M. Nelson, Ronald P Jean, +4 authors Christopher S. Chen
Proceedings of the National Academy of Sciences…
2005

Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of… (More)

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Jordan S Miller, Kelly R Stevens, +10 authors Christopher S. Chen
2017

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

Daniel E Conway, Mark T. Breckenridge, Elizabeth R. Hinde, Enrico Gratton, Christopher S. Chen, Martin A Schwartz
Current Biology
2013

Fluid shear stress (FSS) from blood flow acting on the endothelium critically regulates vascular morphogenesis, blood pressure, and atherosclerosis. FSS applied to endothelial cells (ECs) triggers… (More)

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