Christopher S. Alia

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CD8+ T cell recognition of viral antigens presented by lung epithelial cells is important in the clearance of respiratory viral infection but may cause considerable injury to the lung. We have shown that a critical event of this type of injury is the activation of target epithelial cells and expression of chemokines by these cells. In this study, epithelial(More)
Influenza infection results in considerable pulmonary pathology, a significant component of which is mediated by CD8(+) T cell effector functions. To isolate the specific contribution of CD8(+) T cells to lung immunopathology, we utilized a nonviral murine model in which alveolar epithelial cells express an influenza antigen and injury is initiated by(More)
Chilakamarti V. Ramana,* Matthew P. DeBerge,* Aseem Kumar, Christopher S. Alia, Joan E. Durbin, and Richard I. Enelow Department of Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, New Hampshire; Department of Pathology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Chemistry and Biochemistry,(More)
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