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- David W. Macdonald, Ryan S. Squires, +6 authors Robert E. Seegmiller
- International journal of molecular sciences
- 2013
Heterozgyous spondyloepiphyseal dysplasia congenita (sedc/+) mice expressing a missense mutation in col2a1 exhibit a normal skeletal morphology but early-onset osteoarthritis (OA). We have recently… (More)
- Irene Litvan, Peter S. J. Lees, +11 authors David R Shprecher
- Movement disorders : official journal of the…
- 2016
BACKGROUND
The cause of progressive supranuclear palsy (PSP) is largely unknown. Based on evidence for impaired mitochondrial activity in PSP, we hypothesized that the disease may be related to… (More)
- Martin C. Tammemägi, C Berg, Thomas L. Riley, Christopher R. Cunningham, Kathryn L. Taylor
- Journal of the National Cancer Institute
- 2014
BACKGROUND
Lung cancer screening programs may provide opportunities to reduce smoking rates among participants. This study evaluates the impact of lung cancer screening results on smoking cessation.… (More)
- Connie Marras, Christopher R. Cunningham, +10 authors Irene Litvan
- Parkinsonism & related disorders
- 2018
BACKGROUND
Anti-inflammatory drug use, particularly ibuprofen, has been associated with a lower risk of Parkinson's disease. Microglial activation and inflammatory cytokine expression have been shown… (More)
- David M Brody, Irene Litvan, +5 authors Christopher R. Cunningham
- Movement disorders : official journal of the…
- 2016
INTRODUCTION
The pathophysiology of both PD and PSP is characterized by a pro-oxidant state. Uric acid is an oxidative stress marker. High uric acid blood levels have been associated with a reduced… (More)
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