Christopher R. Winkler

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Many factors have contributed to the inability to successfully employ a marker-based selection scheme for The advent of high throughput molecular technologies has led to complex traits. One major difficulty has been the effec-an expectation that breeding programs will use marker–trait associations to conduct marker-assisted selection (MAS) for traits. Many(More)
The common assumption in quantitative trait locus (QTL) linkage mapping studies that parents of multiple connected populations are unrelated is unrealistic for many plant breeding programs. We remove this assumption and propose a Bayesian approach that clusters the alleles of the parents of the current mapping populations from locus-specific identity by(More)
Two outlines for mixed model based approaches to quantitative trait locus (QTL) mapping in existing maize hybrid selection programs are presented: a restricted maximum likelihood (REML) and a Bayesian Markov Chain Monte Carlo (MCMC) approach. The methods use the in-silico-mapping procedure developed by Parisseaux and Bernardo (2004) as a starting point. The(More)
Genetic regulation is a key component in development, but a clear understanding of the structure and dynamics of genetic networks is not yet at hand. In this work we investigate these properties within an artificial genome model originally introduced by Reil [15]. We analyze statistical properties of randomly generated genomes both on the sequence-and(More)
Genetic regulation is a key component in development, but a clear understanding of the structure and dynamics of genetic networks is not yet at hand. In this paper we investigate these properties within an artificial genome model originally introduced by Reil [17]. We analyze statistical properties of randomly generated genomes both on the sequence-and(More)
Diagnosing a coupled system with linear inverse modelling (LIM) can provide insight into the nature and strength of the coupling. This technique is applied to the cold season output of the GFDL GCM, forced by observed tropical Pacific SSTs and including a slab mixed layer ocean model elsewhere. It is found that extratropical SST anomalies act to enhance(More)
The switching of domains in ferroelectric and multiferroic materials plays a central role in their application to next-generation computer systems, sensing applications, and memory storage. A detailed understanding of the response to electric fields and the switching behavior in the presence of complex domain structures and extrinsic effects (e.g., defects(More)
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