Christopher R Schumann

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In a retrospective 6-year follow-up, we assessed the reasons for and the frequency and consequences of non-adherence in 76 affectively ill patients receiving lithium prophylaxis in two lithium clinics. Thirty-eight bipolar (50%), 21 unipolar (27.6%) and 17 schizoaffective patients (22.4%) diagnosed according to DSM-III-R, were investigated with a(More)
BACKGROUND Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood. METHODS Thirty-two patients with posttraumatic headache following whiplash injury were investigated within 14 days after the accident and again after 3 months using magnetic(More)
BACKGROUND Pompe disease (Glycogen storage disorder type II) is an inherited disease because of a lack or reduced activity of the enzyme alpha-1,4-glucosidase (acid maltase). Since 2006, an intravenous enzyme replacement therapy (ERT) with Myozyme (Genzyme Corporation, Cambridge, MA, USA) is available. METHODS Four adult patients aged between 39 and 68(More)
A number of association studies have investigated the role of the monoamine oxidase A (MAOA) gene in the susceptibility to bipolar disorder. Although some studies have reported positive findings, there remains some controversy, because results from different studies have not been consistent. A common explanation for inconsistencies between studies is(More)
Several studies have indicated that patients with bipolar disorder (BD) who respond well to lithium prophylaxis constitute a biologically distinct subgroup. Lithium is thought to stabilize mood by acting at the phosphoinositide cycle. We have investigated a polymorphism located in the gene (PLCG1) that codes for a gamma-1 isozyme of phospholipase (PLC), an(More)
OBJECTIVE To test for genetic linkage and association with GABAergic candidate genes in lithium-responsive bipolar disorder. DESIGN Polymorphisms located in genes that code for GABRA3, GABRA5 and GABRB3 subunits of the GABAA receptor were investigated using association and linkage strategies. PARTICIPANTS A total of 138 patients with bipolar 1 disorder(More)
Endocrine-disrupting compounds (EDCs) may interfere with neuronal development due to high levels of accumulation in biological tissue and potentially aberrant steroid signaling. Treatment of dissociated embryonic Xenopus spinal cord neurons with the EDC, nonylphenol (NP), did not alter cell survival or neurite outgrowth but inhibited neurotrophin-induced(More)
  • Short Papers, C Rieder, C Brachmann, B Hofmann, J Klein, A Köhn +4 others
  • 2013
Magnetic resonance imaging is a technique which is routinely used by neuroradiologists. Within the last decade, several techniques have been developed to visualize those MR images so that medical experts, and thus the patients , can benefit from it. However, very little work has been done to use neuroanatomical MR data for educational purposes and to bring(More)
Expressive and efficient visualizations of complex vascular structures are essential for medical applications, such as diagnosis and therapy planning. A variety of techniques has been developed which provide smooth high-quality visualizations of vascular structures based on rather simple model assumptions. For diagnostic applications, these model(More)