Christopher R H Newton

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BACKGROUND Recent data have demonstrated that intensive glycemic control during critical illness improves outcome. The purpose of our study was to evaluate the effect of a computerized hospital insulin protocol (CHIP) on glycemic control and outcome in critically ill trauma patients. METHODS Two, 6-month cohorts were compared, one 6 months prior to chip(More)
One hundred and fifty-eight epileptic patients belonging to the Nguni tribe in Transkei were interviewed and examined; electro- encephalograms (EEGs) were recorded in 104. Partial epilepsy with secondary generalized seizures was diagnosed in 59%. Head trauma appeared to be the main aetiological factor in 18%. Thirty-five percent of the EEGs taken showed(More)
The effectiveness of 5 different solutions on the absorption of fluid and electrolytes was tested in 7 patients with a proximal intestinal stoma and large fluid losses, all of whom previously needed intravenous infusions to maintain balance. In 4 patients it proved possible to replace the intravenous infusions with an enteral supplement. The WHO(More)
BACKGROUND Angiotensin II (Ang II) is a potent vasoconstrictor that is released during shock and sepsis. It is known to have activity on vascular endothelial cells. We hypothesized that Ang II plays a role in the modulation of fluid flux across the microvascular endothelium. MATERIALS AND METHODS Hydraulic permeability (L(p)) is a measure of water flow(More)
BACKGROUND We sought to examine the impact of race on the management and outcomes of appendicitis in children aged 20 years or younger. METHODS We studied 96,865 inpatient admissions for children undergoing an appendectomy for acute appendicitis in 2009 using the Kids' Inpatient Database. RESULTS Perforation at presentation was more common among(More)
BACKGROUND Platelet-activating factor (PAF) is a modulator of the inflammatory response to shock. Edema formation and intravascular fluid loss have been associated with PAF. The increase in microvessel permeability caused by PAF may be related to direct endothelial cell activation and leukocyte activation. We hypothesized that PAF increases hydraulic(More)
Duplicate gallbladder is a rare congenital anomaly resulting from abnormalities in embryogenesis during the fifth and sixth weeks of gestation. Approximately 210 cases have been described. Variations include duplicate, triplicate, and septated gallbladder. We encountered a 15-year-old girl with both a duplicated gallbladder and a duplicated cystic duct who(More)
PURPOSE To examine the trends in laparoscopic appendectomy (LA) utilization and outcomes for children 5 years or younger. METHODS We studied 16,028 inpatient admissions for children 5 years of age or less undergoing an appendectomy for acute appendicitis in 2000, 2003, and 2006 using the Kids' Inpatient Database (KID). Laparoscopy frequency, hospital(More)
BACKGROUND Morbid obesity continues to be a significant problem within the United States, as overweight/obesity rates are nearing 33%. Bariatric surgery has had success in treating obesity in adults and is becoming a viable treatment option for obese adolescents. METHODS We studied 1615 inpatient admissions for children ≤20 years of age undergoing a(More)
Bowel habit has been studied in a group of 92 outpatients with ileorectal anastomosis for ulcerative colitis and compared with that in a group of 45 outpatients with ileorectal anastomosis for colonic polyposis. Bowel frequency ranged from 1-7 to 8-7 stools per 24 hours with a mean of 4-5 in the colitic group compared with a range of 1-3 to 8-1 stools per(More)