Christopher R. Fellows

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Keywords: Articular cartilage Subchondral bone Proteomics Osteoarthritis Osteoarthritis (OA) is the most common age-related degenerative joint disorder. It is considered a disease of the entire joint, which is not simply a result of attrition but rather abnormal remodelling and co-alescent failure of multiple tissues. Despite the prevalence of OA,(More)
Current cell-based repair strategies have proven unsuccessful for treating cartilage defects and osteoarthritic lesions, consequently advances in innovative therapeutics are required and mesenchymal stem cell-based (MSC) therapies are an expanding area of investigation. MSCs are capable of differentiating into multiple cell lineages and exerting paracrine(More)
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