Christopher Pirie

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Careful pathological examination of lumbar spines removed at autopsy has shown that degenerative changes are present in the intervertebral discs of all subjects by middle age. The degenerative changes are more marked and occur at an earlier age when evidence of vertical or posterior disc prolapse is also present. Degenerative changes in the discs are always(More)
BACKGROUND Release of growth hormone (GH), putatively through alterations in insulin growth factor-1 (IGF-1) levels, has been implicated to influence left ventricular (LV) myocardial structure and function. The objective of this study was to determine contributory mechanisms by which GH supplementation may influence LV function with the development of(More)
AIMS To determine whether remodelling of subchondral bone in osteoarthritis is related to anatomical and mechanical factors operating on the joint surface. METHODS Ten femoral heads were examined. Patients due to have the femoral head removed because of osteoarthritis were given a double tetracycline label before surgery. The specimens were divided in(More)
A canine implant study was performed to assess whether hydroxyapatite (HA) could induce bone to close gaps at the bone-prosthesis junction. Titanium alloy (TiAlV) plates with varying grooves cut into them (1, 2, and 3 mm deep) and identical on both sides were sprayed on one side with HA and left as bare metal on the other. These were then implanted into the(More)
Twenty-seven femoral heads were obtained at operation from patients with osteoarthrosis and two from patients with rheumatoid arthritis. Twenty of the osteoarthrosic and one of the rheumatoid patients were given oxytetracycline for between three and fourteen days immediately before operation. Oxytetracycline is deposited in newly formed bone and fluoresces(More)
BACKGROUND Exogenous administration of growth hormone (GH) and subsequently increased production of insulin-like growth factor-1 can influence left ventricular (LV) myocardial growth and geometry in the setting of congestive heart failure (CHF). This study determined the effects of an orally active GH secretagogue (GHS) treatment that causes a release of(More)
The tidemark is a metabolically active zone in the calcified layer of the cartilage in which it is possible to show that there is calcifying activity even over a short period of time using a tetracycline labelling technique. The tidemark slowly advances in the direction of the non-calcified cartilage and analysis of double-tetracycline labelled cartilage(More)