Christopher Patrick Gilmore

Learn More
BACKGROUND Substantial grey matter (GM) demyelination occurs in both the cerebral cortex and spinal cord in multiple sclerosis (MS). GM demyelination also occurs in the cerebellar cortex and the deep GM nuclei of the brain. However, no study has made a direct "within subject" comparison of the extent of GM pathology between these regions. AIM To examine(More)
The extent and pattern of gray matter (GM) demyelination in the spinal cord in multiple sclerosis (MS) has not been examined in detail. Human autopsy material was obtained from 36 MS cases and 12 controls. Transverse sections were taken from five levels of the spinal cord (upper cervical, lower cervical, upper thoracic, lower thoracic and lumbar levels) and(More)
The issue of when to initiate treatment in multiple sclerosis (MS) is a contentious one. Four studies have convincingly demonstrated that treatment with beta interferon or glatiramer acetate following an inaugural demyelinating event (a clinically isolated syndrome; CIS) can delay the onset of a second episode, i.e., clinically definite MS (CDMS), although(More)
BACKGROUND Post-mortem studies demonstrate extensive grey matter demyelination in MS, both in the brain and in the spinal cord. However the clinical significance of these plaques is unclear, largely because they are grossly underestimated by MR imaging at conventional field strengths. Indeed post-mortem MR studies suggest the great majority of lesions in(More)
Protein adsorption and growth of primary human osteoblasts on self-assembled monolayers of alkylthiols on gold (SAMs) with carboxylic acid and hydroxyl and methyl termini were investigated. Single-component SAMs and SAMs patterned by photolithographic techniques were used. Cell growth on patterned SAMs demonstrated preferences for one pattern region in all(More)
OBJECTIVE To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS). DESIGN Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas. SETTING Department of Neuropathology, University of(More)
The objective of this study was to assess neuronal pathology in the spinal cord in multiple sclerosis (MS), both within myelinated and demyelinated tissue. Autopsy material was obtained from 38 MS cases and 21 controls. Transverse sections were taken from three spinal cord levels and stained using Luxol Fast Blue/Cresyl Violet and myelin protein(More)
A 48 year old lady presented with a month’s history of vertigo, nausea, and vomiting. Examination revealed nystagmus, mild limb-clumsiness (predominantly left sided) and mild gait ataxia. MR imaging demonstrated diffuse signal change within the cerebellar hemispheres (most prominent on the left), predominantly affecting the white matter but also the(More)