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Supramolecular and biomacromolecular enhancement of metal-free magnetic resonance imaging contrast agents† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc05510j
Supramolecular/macromolecular organic radical contrast agents (smORCAs) overcome many of the limitations of nitroxide radicals for use in magnetic resonance imaging in vivo like poor stability andExpand
Glycosaminoglycan‐induced activation of the β‐secretase (BACE1) of Alzheimer’s disease
J. Neurochem. (2010) 112, 1552–1561.
Supramolecular and Biomacromolecular Enhancement of Metal-Free Magnetic Resonance Imaging Contrast Agents
Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives,Expand
Assembly and performance of a 6.4 T cryogen‐free dynamic nuclear polarization system
The relatively high 13C polarization levels achieved in this work have demonstrated that the use of a cryogen‐free superconducting magnet for 13C DNP is feasible and in fact, relatively efficient—a major leap to offset the high cost of liquid helium consumption in DNP experiments. Expand
Transition Metal Doping Reveals Link between Electron T1 Reduction and 13C Dynamic Nuclear Polarization Efficiency.
This work provides a direct evidence that electron T1 reduction of the polarizing agent by a paramagnetic additive is an essential requirement for the improvement seen in solid-state 13C DNP signal. Expand
13C Dynamic Nuclear Polarization Using a Trimeric Gd3+ Complex as an Additive.
The use of a trimeric gadolinium complex as a dopant in 13C DNP samples to improve the DNP signals in the solid-state and W-band electron paramagnetic resonance (EPR) data have revealed that 3-Gd doping significantly reduces the electron T1 of the trityl OX063 free radical but produces negligible changes in the EPR spectrum, reminiscent of the results with monomeric Gd3+-complex doping. Expand
Impact of Ho(3+)-doping on (13)C dynamic nuclear polarization using trityl OX063 free radical.
The results here suggest that Ho(3+)-doping is advantageous over Gd(3+) in terms of preservation of hyperpolarized state-an important aspect to consider for in vitro and in vivo NMR or imaging (MRI) experiments where a considerable preparation time is needed to administer the hyperPolarized (13)C liquid. Expand
Influence of Dy3+ and Tb3+ doping on 13C dynamic nuclear polarization.
Dy 3+ doping and Tb3+ doping have a beneficial impact on C13 DNP both in the solid and liquid states, and that Tb 3+ in particular could be used as a potential alternative to Gd3+ in C13 dissolution DNP experiments. Expand
13C dynamic nuclear polarization using isotopically enriched 4‐oxo‐TEMPO free radicals
The data here suggest that the hyperfine coupling contributions of these isotopically enriched 4‐oxo‐TEMPO free radicals have negligible effects on the 13C DNP efficiency at 3.35 T and 1.2 K. Expand
Construction and 13C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system
Considering the relatively lower cost of the homebuilt DNP system and the relative simplicity of its design, the dissolution DNP setup reported here could be feasibly adapted for in vitro or in vivo hyperpolarized 13C NMR or magnetic resonance imaging at least in the pre‐clinical setting. Expand