Christopher P. Appleton

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Sherif F. Nagueh, MD, Chair, Christopher P. Appleton, MD, Thierry C. Gillebert, MD,* Paolo N. Marino, MD,* Jae K. Oh, MD, Otto A. Smiseth, MD, PhD,* Alan D. Waggoner, MHS, Frank A. Flachskampf, MD, Co-Chair,* Patricia A. Pellikka, MD, and Arturo Evangelista, MD,* Houston, Texas; Phoenix, Arizona; Ghent, Belgium; Novara, Italy; Rochester, Minnesota; Oslo,(More)
BACKGROUND Noninvasive assessment of diastolic filling by Doppler echocardiography provides important information about left ventricular (LV) status in selected subsets of patients. This study was designed to assess whether mitral annular velocities as assessed by tissue Doppler imaging are associated with invasive measures of diastolic LV performance and(More)
Sherif F. Nagueh, Chair, MD, FASE, Otto A. Smiseth, Co-Chair, MD, PhD, Christopher P. Appleton, MD, Benjamin F. Byrd, III, MD, FASE, Hisham Dokainish, MD, FASE, Thor Edvardsen, MD, PhD, Frank A. Flachskampf, MD, PhD, FESC, Thierry C. Gillebert, MD, PhD, FESC, Allan L. Klein, MD, FASE, Patrizio Lancellotti, MD, PhD, FESC, Paolo Marino, MD, FESC, Jae K. Oh,(More)
OBJECTIVES We sought to test whether the ratio of peak tricuspid regurgitant velocity (TRV, ms) to the right ventricular outflow tract time-velocity integral (TVI(RVOT), cm) obtained by Doppler echocardiography (TRV/TVI(RVOT)) provides a clinically reliable method to determine pulmonary vascular resistance (PVR). BACKGROUND Pulmonary vascular resistance(More)
Left atrial (LA) enlargement has been proposed as a barometer of diastolic burden and a predictor of common cardiovascular outcomes such as atrial fibrillation, stroke, congestive heart failure, and cardiovascular death. It has been shown that advancing age alone does not independently contribute to LA enlargement, and the impact of gender on LA volume can(More)
BACKGROUND Increased left atrial (LA) size and reduced global contractility are related to adverse cardiac events. The potential incremental value of assessing regional LA contractility is unknown. To assess the feasibility of measuring this variable angle, independent 2-dimensional speckle-tracking strain echocardiography (2D-SpTr) was used to measure(More)
OBJECTIVES The purpose of this study was to determine whether left atrial size and ejection fraction are related to left ventricular filling pressures in patients with coronary artery disease. BACKGROUND In patients with coronary artery disease, left ventricular filling pressures can be estimated by using Doppler mitral and pulmonary venous flow velocity(More)
In an effort to determine what clinically useful information regarding left ventricular diastolic function can be inferred noninvasively with pulsed wave Doppler echocardiography, mitral flow velocity patterns and measured variables were correlated with hemodynamic findings in 70 patients: 30 with coronary artery disease, 20 with idiopathic congestive(More)
Abnormalities of diastolic filling are increasingly recognized as a cause of symptoms and predictors of outcome in patients with most forms of heart disease. Noninvasive assessment of diastolic filling is possible in almost all patients, but accurate evaluation must relate echocardiographic Doppler measurements to the complex physiologic and hemodynamic(More)
We performed a simultaneous Doppler and invasive study to validate the role of Doppler-derived peak pulmonary regurgitant velocity as a reliable noninvasive measure of pulmonary artery mean pressure. Assessment of right atrial pressure, as shown in this study, enhances the use of this Doppler parameter as a correlate of pulmonary artery mean pressure.