Pier Paolo Pandolfi3
Min Sup Song2
Kaitlyn Webster2
3Pier Paolo Pandolfi
2Min Sup Song
2Kaitlyn Webster
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Tumor cells metastasize to distant organs through genetic and epigenetic alterations, including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial-mesenchymal transition (EMT), enhances invasiveness and promotes metastasis in mouse xenografts. In a conditional mammary gland-specific transgenic (TG) mouse model, we show that miR-22(More)
  • Antonella Papa, Lixin Wan, Massimo Bonora, Leonardo Salmena, Min Sup Song, Robin M. Hobbs +13 others
  • 2014
PTEN dysfunction plays a crucial role in the pathogenesis of hereditary and sporadic cancers. Here, we show that PTEN homodimerizes and, in this active conformation, exerts lipid phosphatase activity on PtdIns(3,4,5)P3. We demonstrate that catalytically inactive cancer-associated PTEN mutants heterodimerize with wild-type PTEN and constrain its phosphatase(More)
Coordination between ensembles of improvising electroacoustic musicians is a special case of the larger HCI problem of coordinating joint, real-time activity; one that involves some interesting additional and different challenges. This paper reports on research that has identified two specific real-time coordination problems for ensembles of electroacoustic(More)
Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments demonstrated that pseudogenes contribute to cell transformation through several mechanisms. However, in vivo evidence for a causal role of pseudogenes in cancer development is lacking. Here, we report that mice engineered to(More)
OBJECTIVE This study examines the influence of posture on the range of axial rotation of the thorax and the range and direction of the coupled lateral flexion. METHODS The ranges of mid thoracic axial rotation and coupled lateral flexion were measured in 52 asymptomatic subjects (aged 18-43 years) using an optical motion analysis system. To examine the(More)
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