Christopher Mueller

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In this study, we examine the use of graph ordering algorithms for visual analysis of data sets using visual similarity matrices. Visual similarity matrices display the relationships between data items in a dot-matrix plot format, with the axes labeled with the data items and points drawn if there is a relationship between two data items. The biggest(More)
Visual similarity matrices (VSMs) are a common technique for visualizing graphs and other types of relational data. While traditionally used for small data sets or well-ordered large data sets, they have recently become popular for visualizing large graphs. However , our experience with users has revealed that large VSMs are difficult to interpret. In this(More)
Many applications in Comparative Genomics lend themselves to implementations that take advantage of common high-performance features in modern microprocessors. However, the common suggestion that a data-parallel, multithreaded, or high-throughput implementation is possible often ignores the complexity of actually creating such software. In this paper, we(More)
While there exist many interactive tools for the visualization of small graphs and networks, these tools do not address the fundamental problems associated with the visualization of large graphs. In particular, larger graphs require much larger display areas (e.g., display walls) to reduce visual clutter, allowing users to determine the structure of large(More)
The tumor necrosis factor superfamily (TNFSF) members play pivotal roles in embryonic development of lymphoid tissue and their homeostasis. RANKL (Receptor activator of NF-κB ligand, also called TRANCE, TNFSF11) is recognized as an important player in bone homeostasis and lymphoid tissue formation. In its absence bone mass control is deregulated and lymph(More)
Scripting languages are ubiquitous in modern software engineering and are often used as the sole language for application development. However, some applications, specifically scientific and multimedia applications, often have small sections of code that require a higher level of performance than the host language can deliver. In many cases, the algorithm(More)
BACKGROUND An important question in dengue pathogenesis is the identity of immune cells involved in the control of dengue virus infection at the site of the mosquito bite. There is evidence that infection of immature myeloid dendritic cells plays a crucial role in dengue pathogenesis and that the interaction of the viral envelope E glycoprotein with(More)
To simultaneously provide rapid application development and high performance, developers of scientific and multimedia applications often mix languages, using scripting languages to glue together high-performance components written in compiled languages. While this can be a useful development strategy, it distances application developers from the(More)
The MSX2 homeoprotein is implicated in all aspects of craniofacial skeletal development. During postnatal growth, MSX2 is expressed in all cells involved in mineralized tissue formation and plays a role in their differentiation and function. Msx2 null (Msx2 (-/-)) mice display complex craniofacial skeleton abnormalities with bone and tooth defects. A(More)