Christopher Michael Hill

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The current revolution in genomics has been made possible by software tools called genome assemblers, which stitch together DNA fragments “read” by sequencing machines into complete or nearly complete genome sequences. Despite decades of research in this field and the development of dozens of genome assemblers, assessing and comparing the quality of(More)
Accurate sequence and assembly of genomes is a critical first step for studies of genetic variation. We generated a high-quality assembly of the gorilla genome using single-molecule, real-time sequence technology and a string graph de novo assembly algorithm. The new assembly improves contiguity by two to three orders of magnitude with respect to previously(More)
This study assesses themonthly climatology of the timing and placement of convective precipitation events induced by sea and land breezes in the Louisiana–Mississippi–Alabama region, and determines possible reasons for the monthly differences. These objectives were achieved through surface wind climatologies and radar composites from 2003 to 2005,(More)
The continued democratization of DNA sequencing has sparked a new wave of development of genome assembly and assembly validation methods. As individual research labs, rather than centralized centers, begin to sequence the majority of new genomes, it is important to establish best practices for genome assembly. However, recent evaluations such as GAGE and(More)
In 1980 the Holland tropical cyclone (TC) wind profile model was introduced. This simple model was originally intended to estimate the wind profile based on limited surface pressure information alone. For this reason and its relative simplicity, the model has been used in many practical applications. In this paper the potential of a simplified version of(More)
Using simulated data to develop and study diagnostic tools for data analysis is very beneficial. The user can gain insight about what happens when assumptions are violated since the true model is known. However, care must be taken to be sure that the simulated data is a reasonable representation of what one would usually expect in the real world. This paper(More)
Metagenomic assemblers inherit all the difficulties of traditional single genome assembly, but with the additional complexity of trying to resolve assemblies of closely related species with drastically varying abundances. Assessing and comparing the quality of single genome assembly still relies on the availability of independently determined standards,(More)
Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of diarrhea worldwide. Among the 25 different ETEC adhesins, 22 are known as "colonization factors" (CFs), of which 17 are assembled by the chaperone-usher (CU) mechanism. Currently, there is no preventive therapy against ETEC, and CFs have been proposed as components for vaccine(More)
Title of dissertation: NOVEL METHODS FOR COMPARING AND EVALUATING SINGLE AND METAGENOMIC ASSEMBLIES Christopher Michael Hill, Doctor of Philosophy, 2015 Dissertation directed by: Professor Mihai Pop Department of Computer Science The current revolution in genomics has been made possible by software tools called genome assemblers, which stitch together DNA(More)